P8783

Progesterone

powder, BioReagent, suitable for cell culture

• Synonyme(s) : 4-Pregnene-3,20-dione
• Formule empirique (notation de Hill): C₂₁H₃₀O₂
• Numéro CAS: 57-83-0
• Poids moléculaire : 314.46
• Numéro Beilstein : 1915950
• Numéro CE : 200-350-6
• Numéro MDL: MFCD00003658
• Code UNSPSC : 12352209
• ID de substance PubChem : 24898978
• Nomenclature NACRES : NA.77

Propriétés

• Source biologique: synthetic (organic)
• Niveau de qualité: 200
• Description: synthesized from materials derived from plant source
• Gamme de produits: BioReagent
• Pureté: ≥99%
• Forme: powder
• Puissance: 0.1-20 ng/mL
• Technique(s): cell culture | mammalian: suitable
• Pf: 128-132 °C (lit.)
• Solubilité: absolute ethanol: 1 mg/mL
• Température de stockage: room temp
• Chaîne SMILES: CC(=O)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C
• InChI: 1S/C21H30O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12,16-19H,4-11H2,1-3H3/t16-,17+,18-,19-,20-,21+/m0/s1
• Clé InChI: RJKFOVLPORLFTN-LEKSSAKUSA-N
• Informations sur le gène: human ... ABCB1(5243) , AR(367) , CYP2C9(1559) , EBP(10682) , ESR1(2099) , ESR2(2100) , NR3C1(2908) , NR3C2(4306) , PGR(5241) , SERPINA6(866) ; mouse ... Esr1(13982) ; rat ... Ar(24208) , Nr3c1(24413) , Pgr(25154)

Description

Description générale

Progesterone is a steroid hormone secreted by the ovaries.

Application

Progesterone has been used:

• as a growth-promoting hormone in basal medium for bovine mammary epithelial cell culture
• to test its neuroprotective abilities in a well-characterized lateral cortical contusion injury (CCI) model
• as an endocytosis inhibitor to study its effect on Coxsackievirus A9 infection on A549 cells

Use in cell culture applications to study sterol regulation of cell signaling and gene expression.

Actions biochimiques/physiologiques

Induces maturation and secretory activity of the uterine endothelium; suppresses ovulation. Progesterone is implicated in the etiology of breast cancer.

Progesterone is a hormone that maintains pregnancy. It is essential for embryo formation, development and survival in almost all mammals. This hormone exhibits its action via progesterone receptor, which is specifically expressed in the endometrial stroma throughout pregnancy. It is known to prevent preterm delivery, when administered intramuscularly. Progesterone also controls gonadotropin secretion, activates sexual behavior and triggers ovarian events leading to ovulation. It stimulates the growth and differentiation of the uterus and prevents uterine contractility.

Autres remarques

Steroid hormone produced by the corpus luteum.

Forme physique

powder-RT; stock-frozen in working aliquots, avoid repeated freeze/thaw

Reconstitution

To prepare 20μg/ml stock solution, add 1ml absolute ethanol per mg progesterone, gently swirl to dissolve, add 49ml sterile medium per ml ethanol.

Informations sur la sécurité

• Pictogrammes: GHS08
• Mention d'avertissement: Danger
• Mentions de danger: H351,H360FD,H362
• Conseils de prudence: P202 - P260 - P263 - P264 - P280 - P308 + P313
• Classification des risques: Carc. 2 - Lact. - Repr. 1A
• Code de la classe de stockage: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type P3 (EN 143) respirator cartridges