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Y0001094

Aceclofenac for peak identification

European Pharmacopoeia (EP) Reference Standard

Synonyme(s) :

Aceclofenac, 2-[(2,6-Dichlorophenyl)amino]benzeneacetic acid carboxymethyl ester;

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About This Item

Formule empirique (notation de Hill):
C16H13Cl2NO4
Numéro CAS:
89796-99-6
Poids moléculaire :
354.18
Numéro MDL:
MFCD00864296
Code UNSPSC :
41116107
ID de substance PubChem :
329831261
Nomenclature NACRES :
NA.24

Qualité

pharmaceutical primary standard

Famille d'API

aceclofenac

Fabricant/nom de marque

EDQM

Application(s)

pharmaceutical (small molecule)

Format

neat

Température de stockage

2-8°C

Chaîne SMILES 

OC(=O)COC(=O)Cc1ccccc1Nc2c(Cl)cccc2Cl

InChI

1S/C16H13Cl2NO4/c17-11-5-3-6-12(18)16(11)19-13-7-2-1-4-10(13)8-15(22)23-9-14(20)21/h1-7,19H,8-9H2,(H,20,21)

Clé InChI

MNIPYSSQXLZQLJ-UHFFFAOYSA-N

Informations sur le gène

human ... PTGS2(5743)

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Description générale

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Aceclofenac for peak identification EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Actions biochimiques/physiologiques

Non-steroidal, anti-inflammatory drug (NSAID), with selectivity for COX-2 over COX-1.

Conditionnement

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Autres remarques

Sales restrictions may apply.

Pictogrammes

Skull and crossbonesEnvironment
GHS06,GHS09

Mention d'avertissement

Danger

Mentions de danger

H301,H319,H410

Classification des risques

Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2

Code de la classe de stockage

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Certificats d'analyse (COA)

Lot/Batch Number

Désolés, nous n'avons pas de COA pour ce produit disponible en ligne pour le moment.

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Consulter la Bibliothèque de documents

M Dooley et al.
Drugs, 61(9), 1351-1378 (2001-08-21)
Aceclofenac is an orally administered phenylacetic acid derivative with effects on a variety of inflammatory mediators. Through its analgesic and anti-inflammatory properties, aceclofenac provides symptomatic relief in a variety of painful conditions. In patients with osteoarthritis of the knee, the
Sanjay Dey et al.
Expert opinion on drug delivery, 9(9), 1041-1050 (2012-07-14)
The objective of the present study was to develop bilayer tablets of aceclofenac that are characterized by initial burst drug release followed by sustained release of drug. The fast-release layer of the bilayer tablet was formulated using microcrystaline cellulose (MCC)
Viney Chawla et al.
Colloids and surfaces. B, Biointerfaces, 92, 293-298 (2012-01-10)
Solid lipid nanoparticles (SLN) of aceclofenac were prepared using Taguchi experimental design by Trotta method. The prepared SLN were formulated into a gel preparation, using carbopol 940. Gels were evaluated for drug content, bioadhesion and their stability against change of
Anil Pareek et al.
The journal of pain : official journal of the American Pain Society, 12(5), 546-553 (2011-02-01)
The efficacy and safety of aceclofenac control release (CR) tablets was compared with conventional aceclofenac tablets in patients with knee osteoarthritis (OA). This was a double-blind, double-dummy, randomized, parallel group multicentric study conducted at 6 centers. Two hundred and eighty
Rajesh Katara et al.
Colloids and surfaces. B, Biointerfaces, 103, 455-462 (2012-12-25)
The purpose of this study was to prepare Eudragit RL 100-based nanoparticles of aceclofenac by nanoprecipitation and evaluate the particle size, zeta potential, drug entrapment, particle morphology; in vitro drug release and in vivo efficacy. Change in drug-polymer ratio from
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