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A8861

Sigma-Aldrich

Aceclofenac

≥98% (HPLC)

Synonyme(s) :

2-[(2,6-Dichlorophenyl)amino]benzeneacetic acid carboxymethyl ester;

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About This Item

Formule empirique (notation de Hill):
C16H13Cl2NO4
Numéro CAS:
89796-99-6
Poids moléculaire :
354.18
Numéro MDL:
MFCD00864296
Code UNSPSC :
12352200
ID de substance PubChem :
329771021
Nomenclature NACRES :
NA.77

Niveau de qualité

100

Pureté

≥98% (HPLC)

Forme

powder

Couleur

off-white to light tan

Solubilité

DMSO: ≥20 mg/mL

Température de stockage

room temp

Chaîne SMILES 

OC(=O)COC(=O)Cc1ccccc1Nc2c(Cl)cccc2Cl

InChI

1S/C16H13Cl2NO4/c17-11-5-3-6-12(18)16(11)19-13-7-2-1-4-10(13)8-15(22)23-9-14(20)21/h1-7,19H,8-9H2,(H,20,21)

Clé InChI

MNIPYSSQXLZQLJ-UHFFFAOYSA-N

Informations sur le gène

human ... PTGS2(5743)

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Application

Aceclofenac (ACE) has been used as an internal standard in the in vivo blood-brain barrier assay. It has also been used to study the interaction of ACE with bovine serum albumin (BSA) by using spectroscopic techniques in combination with computational methods.

Actions biochimiques/physiologiques

Aceclofenac is a phenyl acetic acid derivative used for treating symptoms like swelling, tenderness, and stiffness due to muscle-skeletal and bone-related diseases (rheumatoid arthritis, juvenile arthritis, osteoarthritis, and acute gouty arthritis). This compound shows analgesic and antipyretic properties. Aceclofenac suppresses prostaglandin biosynthesis.
Non-steroidal, anti-inflammatory drug (NSAID), with selectivity for COX-2 over COX-1.

Pictogrammes

Skull and crossbonesEnvironment
GHS06,GHS09

Mention d'avertissement

Danger

Mentions de danger

H301,H319,H410

Classification des risques

Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2

Code de la classe de stockage

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Acétaminophène BioXtra, ≥99.0%

Sigma-Aldrich

A7085

Acétaminophène

S S Kulthe et al.
Colloids and surfaces. B, Biointerfaces, 88(2), 691-696 (2011-08-25)
Pluronic block copolymers offer affluent phase behavioral characteristics and are extensively investigated for drug delivery applications. Hydrophobic Pluronics produce larger aggregates whereas hydrophilic Pluronics often generate small-sized micelles in aqueous milieu. To overcome the limitations and combine the advantages of
R Andrew Moore et al.
The Cochrane database of systematic reviews, (3)(3), CD007588-CD007588 (2009-07-10)
Aceclofenac is the prodrug of the non-steroidal anti-inflammatory drug (NSAID) diclofenac, widely used to treat acute and chronic pain. There are no known systematic reviews of its analgesic efficacy in acute postoperative pain. This review sought to evaluate the efficacy
K Karthikeyan et al.
AAPS PharmSciTech, 13(1), 143-149 (2011-12-15)
Nonsteroidal anti-inflammatory drugs (NSAIDs) induce gastric injury on long-term usage. This study aims at reducing the side effect of NSAIDs by encapsulating in zein, an acid-resistant biopolymer. Aceclofenac-loaded zein microspheres were prepared by emulsification and solvent evaporation method. The stability
An insight into the binding of aceclofenac with bovine serum albumin at physiological condition: a spectroscopic and computational approach.
Neeraj Dohare et al.
Journal of biomolecular structure & dynamics, 36(2), 398-406 (2017-01-25)
Viney Chawla et al.
Colloids and surfaces. B, Biointerfaces, 92, 293-298 (2012-01-10)
Solid lipid nanoparticles (SLN) of aceclofenac were prepared using Taguchi experimental design by Trotta method. The prepared SLN were formulated into a gel preparation, using carbopol 940. Gels were evaluated for drug content, bioadhesion and their stability against change of
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