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Y0000838

Doxepin hydrochloride

European Pharmacopoeia (EP) Reference Standard

Synonyme(s) :

11-(3-Dimethylaminopropylidene)-6,11-dihydrodibenz[b,e]oxepine hydrochloride

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About This Item

Formule empirique (notation de Hill):
C19H21NO · HCl
Numéro CAS:
1229-29-4
Poids moléculaire :
315.84
Numéro MDL:
MFCD00079135
Code UNSPSC :
41116107
ID de substance PubChem :
329831184
Nomenclature NACRES :
NA.24

Qualité

pharmaceutical primary standard

Famille d'API

doxepin

Fabricant/nom de marque

EDQM

Application(s)

pharmaceutical (small molecule)

Format

neat

Température de stockage

2-8°C

Chaîne SMILES 

Cl[H].CN(C)CC\C=C1/c2ccccc2COc3ccccc13

InChI

1S/C19H21NO.ClH/c1-20(2)13-7-11-17-16-9-4-3-8-15(16)14-21-19-12-6-5-10-18(17)19;/h3-6,8-12H,7,13-14H2,1-2H3;1H/b17-11+;

Clé InChI

MHNSPTUQQIYJOT-SJDTYFKWSA-N

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Catégories apparentées

Description générale

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Doxepin hydrochloride EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Conditionnement

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Autres remarques

Sales restrictions may apply.

Produit(s) apparenté(s)

Réf. du produit
Description
Tarif

Y0000851

Doxepin for system suitability, European Pharmacopoeia (EP) Reference Standard

1225511

Doxepin Related Compound A, United States Pharmacopeia (USP) Reference Standard

1225500

Doxepin hydrochloride, United States Pharmacopeia (USP) Reference Standard

1225522

Doxepin Related Compound B, United States Pharmacopeia (USP) Reference Standard

1225533

Doxepin Related Compound C, United States Pharmacopeia (USP) Reference Standard

BP136

Doxepin hydrochloride, British Pharmacopoeia (BP) Reference Standard

BP823

Doxepin impurity standard, British Pharmacopoeia (BP) Reference Standard

PHR8923

Doxepin Related Compound C

PHR8924

Doxepin Related Compound B, Pharmaceutical Secondary Standard; Certified Reference Material

Pictogrammes

Skull and crossbones
GHS06

Mention d'avertissement

Danger

Mentions de danger

H301

Classification des risques

Acute Tox. 3 Oral

Code de la classe de stockage

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Certificats d'analyse (COA)

Lot/Batch Number

Désolés, nous n'avons pas de COA pour ce produit disponible en ligne pour le moment.

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Consulter la Bibliothèque de documents

Haramandeep Singh et al.
Expert opinion on investigational drugs, 16(8), 1295-1305 (2007-08-10)
Low-dose doxepin hydrochloride (1, 3 and 6 mg) is a tricyclic antidepressant currently being investigated for the treatment of primary insomnia in adult and geriatric patients. Although it has been used at much higher doses to treat depression effectively for
Feng Tao et al.
Journal of biochemical and molecular toxicology, 34(2), e22424-e22424 (2019-11-20)
Recent studies have shown that tricyclic antidepressants (TCAs) may have anti-inflammatory and anticonvulsant effects in addition to its antidepressant effects. So far, the nonantidepressant effects of TCAs and their molecular pharmacological mechanisms remain completely unclear. Chronic inflammation in the brain
Grzegorz Jagla et al.
Pharmacological reports : PR, 66(3), 459-465 (2014-06-07)
The therapy of neuropathic pain may include the use of co-analgesics, such as antidepressants, however, their desired analgesic effect is associated with significant side effects. An alternative approach to this is their local administration which has been proposed, but there
Shigeru Hishinuma et al.
Biochemical pharmacology, 91(2), 231-241 (2014-07-30)
Differential binding sites for first- and second-generation antihistamines were indicated on the basis of the crystal structure of human histamine H1 receptors. In this study, we evaluated differences between the thermodynamic driving forces of first- and second-generation antihistamines for human
Alvaro Gimeno et al.
International journal of pharmaceutics, 477(1-2), 650-654 (2014-12-03)
According to previous studies reporting the anesthetic/analgesic action of oral topical doxepin administration, this study evaluated a model of buccal permeation to determine the depth of delivery of doxepin into excised porcine buccal mucosa following topical application of a saturated

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