Accéder au contenu
Merck
Toutes les photos(1)

Key Documents

View All Documentation

SMB01345

Sigma-Aldrich

N-Methyl-2-pyridone-5-carboxamide

Synonyme(s) :

1,6-Dihydro-1-methyl-6 -oxonicotinamide, 1-Methyl-5-carboxylamide-2-pyridone, 2-Py, 2PY, 3-Carbamoyl-1-methyl-6-pyridone, N1-Methyl-2-pyridone-5-carboxamide, Me2PY, Met2PY, Nedifloramide, Nudifloramide

Se connecterpour consulter vos tarifs contractuels et ceux de votre entreprise/organisme
Toutes les photos(1)

About This Item

Formule empirique (notation de Hill):
C7H8N2O2
Numéro CAS:
701-44-0
Poids moléculaire :
152.15
Numéro MDL:
MFCD00457283
Nomenclature NACRES :
NA.77

Pureté

≥95% (HPLC)

Niveau de qualité

100

Forme

solid

Pf

210—21.5 °C

InChI

1S/C7H8N2O2/c1-9-4-5(7(8)11)2-3-6(9)10/h2-4H,1H3,(H2,8,11)

Clé InChI

JLQSXXWTCJPCBC-UHFFFAOYSA-N

Description générale

N-methyl-2-pyridone-5-carboxamide (2PY) is one of the end products of nicotinamide-adenine dinucleotide (NAD) degradation. Increased serum 2PY concentrations are observed in chronic renal failure (CRF) patients, which along with the deterioration of kidney function and its toxic properties (significant inhibition of PARP-1), suggests that 2PY is an uremic toxin.

Application

Metabolomics research

Autres remarques

For additional information on our range of Biochemicals, please complete this form.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Faites votre choix parmi les versions les plus récentes :

Certificats d'analyse (COA)

Lot/Batch Number
MKCT8881
MKCQ5660

Vous ne trouvez pas la bonne version ?

Si vous avez besoin d'une version particulière, vous pouvez rechercher un certificat spécifique par le numéro de lot.

Rechercher un(e) COA

Déjà en possession de ce produit ?

Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Boleslaw Rutkowski et al.
Kidney international. Supplement, (84), S19-S21 (2003-04-16)
N-methyl-2-pyridone-5-carboxamide (2PY) is one of the end products of nicotinamide-adenine dinucleotide (NAD) degradation. We recently found that serum 2PY concentrations in chronic renal failure (CRF) patients were enhanced to the values, which are potentially toxic. The aim of this study
Carolien P J Deen et al.
Nutrients, 12(7) (2020-07-16)
It is unclear whether niacin nutritional status is a target for improvement of long-term outcome after renal transplantation. The 24-h urinary excretion of N1-methylnicotinamide (N1-MN), as a biomarker of niacin status, has previously been shown to be negatively associated with
Renata Novak Kujundžić et al.
International journal of molecular sciences, 22(11) (2021-06-03)
The activity of nicotinamide N-methyltransferase (NNMT) is tightly linked to the maintenance of the nicotinamide adenine dinucleotide (NAD+) level. This enzyme catalyzes methylation of nicotinamide (NAM) into methyl nicotinamide (MNAM), which is either excreted or further metabolized to N1-methyl-2-pyridone-5-carboxamide (2-PY)
Flore Duranton et al.
Journal of the American Society of Nephrology : JASN, 23(7), 1258-1270 (2012-05-26)
An updated review of the existing knowledge regarding uremic toxins facilitates the design of experimental studies. We performed a literature search and found 621 articles about uremic toxicity published after a 2003 review of this topic. Eighty-seven records provided serum

Notre équipe de scientifiques dispose d'une expérience dans tous les secteurs de la recherche, notamment en sciences de la vie, science des matériaux, synthèse chimique, chromatographie, analyse et dans de nombreux autres domaines..

Contacter notre Service technique