F6377

Fluorescein sodium salt

Powder

• Synonyme(s) : Acid Yellow 73, D&C;Yellow No. 8, NaFl, NaFluo, Sodium fluorescein, Uranine
• Formule empirique (notation de Hill): C₂₀H₁₀Na₂O₅
• Numéro CAS: 518-47-8
• Poids moléculaire : 376.27
• Numéro C.I. (Colour Index): 45350
• Numéro Beilstein : 3833041
• Numéro CE : 208-253-0
• Numéro MDL: MFCD00167039
• Code UNSPSC : 12171500
• ID de substance PubChem : 24894907
• Nomenclature NACRES : NA.47

Propriétés

• product name: Fluorescein sodium salt, used as fluorescent tracer
• Niveau de qualité: 200
• Forme: powder
• Technique(s): titration: suitable
• Couleur: orange to brown
• pH: 8.3 (20 °C, 10 g/L)
• Pf: >300 °C
• Solubilité: H₂O: 1 mg/mL
• Densité: 0.78 g/cm³ at 29.6 °C (85.3 °F at 699.7 hPa)
• Fluorescence: λ_ex 460 nm; λ_em 515 nm(lit.)
• Application(s): diagnostic assay manufacturing; hematology; histology
• Température de stockage: room temp
• Chaîne SMILES: [Na+].[Na+].[O-]c1ccc2c(Oc3cc([O-])ccc3C24OC(=O)c5ccccc45)c1
• InChI: 1S/C20H12O5.2Na/c21-11-5-7-15-17(9-11)24-18-10-12(22)6-8-16(18)20(15)14-4-2-1-3-13(14)19(23)25-20;;/h1-10,21-22H;;/q;2*+1/p-2
• Clé InChI: RGPLGPBQJOQFJS-UHFFFAOYSA-L

Description

Description générale

Fluorescein is a xanthene dye and is a common labeling agent in biology.

Application

Fluorescein sodium salt has been used as a solute to study microvessel permeability. It has been used as a test molecule to study blood barrier penetration.

Water soluble fluorescent dye used in permeability and vascular perfusion studies due to its small molecular radius. Sodium fluorescein is used as a fluorescent tracer to study blood-brain barrier (BBB) and blood-spinal cord barrier (BSCB) permeability in rodent models. The dye was used as a probe substrate in the study of organic anion transporting polypeptide (OATP) mediated drug transport in hepatocytes. Sodium fluorescein was also used to monitor in situ solute transportation into bone through fluorescence recovery after photobleaching (FRAP).

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): 423.7 °F - Pensky-Martens closed cup
• Point d'éclair (°C): 217.6 °C - Pensky-Martens closed cup
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)