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D7439

Supelco

Dihydroartemisinin

analytical standard, mixture of α and β isomers

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About This Item

Formule empirique (notation de Hill):
C15H24O5
Poids moléculaire :
284.35
Numéro MDL:
MFCD28384156
Code UNSPSC :
41116107
ID de substance PubChem :
329798850
Nomenclature NACRES :
NA.24

Qualité

analytical standard

Niveau de qualité

200

Pureté

≥97% (TLC)

Forme

powder

Technique(s)

HPLC: suitable
gas chromatography (GC): suitable

Application(s)

pharmaceutical (small molecule)

Format

neat

Température de stockage

2-8°C

Chaîne SMILES 

C[C@H]1C(O)O[C@@]2([H])[C@@]3(OO4)[C@](CC[C@]4(C)O2)([H])[C@H](C)CC[C@]31[H]

InChI

1S/C15H24O5/c1-8-4-5-10-9(2)12(16)18-13-15(10)11(8)6-14(3,7-17-13)19-20-15/h8-13,16H,4-7H2,1-3H3/t8-,9-,10+,11+,12?,13+,14+,15+/m1/s1

Clé InChI

DJGUTYJDEZGRGH-NJEKVMANSA-N

Description générale

Dihydroartemisinin is the major metabolite of the antimalarial agent, artemether. It is highly efficient against both drug-sensitive and drug-resistant strains of Plasmodium falciparum.
Antimalarial; antipsoriasis; anti-inflammatory.

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Avertissement

Protect from light.

Notes préparatoires

artemisia plant extract

Pictogrammes

FlameEnvironment
GHS02,GHS09

Mention d'avertissement

Danger

Mentions de danger

H242,H411

Classification des risques

Aquatic Chronic 2 - Org. Perox. C

Code de la classe de stockage

5.2 - Organic peroxides and self-reacting hazardous materials

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

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Certificats d'analyse (COA)

Lot/Batch Number
0000375586
0000375586
0000254398
SLCM2157
SLCK0307

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Anne Marijon et al.
Malaria journal, 13, 501-501 (2014-12-18)
Improving management of patients suffering from cerebral malaria is needed to reduce the devastating mortality and morbidity of the disease in endemic areas. Intravenous artesunate is currently the first-line treatment, but the lack of material and skills in the field
Zenglei Wang et al.
PloS one, 9(4), e93825-e93825 (2014-04-17)
Malaria elimination/eradication campaigns emphasize interruption of parasite transmission as a priority strategy. Screening for new drugs and vaccines against gametocytes is therefore urgently needed. However, current methods for sexual stage drug assays, usually performed by counting or via fluorescent markers
Selective determination, in plasma, of artemether and its major metabolite, dihydroartemisinin, by high-performance liquid chromatography with ultraviolet detection
Thomas GC, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 583(1), 131-136 (1992)
Aditya S Paul et al.
Nature communications, 11(1), 3532-3532 (2020-07-17)
Asexual proliferation of the Plasmodium parasites that cause malaria follows a developmental program that alternates non-canonical intraerythrocytic replication with dissemination to new host cells. We carried out a functional analysis of the Plasmodium falciparum homolog of Protein Phosphatase 1 (PfPP1)
Thomas R Lane et al.
Antiviral research, 182, 104908-104908 (2020-08-18)
We have recently identified three molecules (tilorone, quinacrine and pyronaridine tetraphosphate) which all demonstrated efficacy in the mouse model of infection with mouse-adapted Ebola virus (EBOV) model of disease and had similar in vitro inhibition of an Ebola pseudovirus (VSV-EBOV-GP)
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