L5420

Lumefantrine

• Synonyme(s) : (9Z)-2,7-Dichloro-9-[(4-chlorophenyl)methylene]-α-[(dibutylamino)methyl]-9H-fluorene-4-methanol, Benflumetol, CPG-56695
• Formule empirique (notation de Hill): C₃₀H₃₂Cl₃NO
• Numéro CAS: 82186-77-4
• Poids moléculaire : 528.94
• Numéro MDL: MFCD05662268
• Code UNSPSC : 12352200
• ID de substance PubChem : 329817625
• Nomenclature NACRES : NA.77

Propriétés

• Pureté: ≥98% (HPLC)
• Niveau de qualité: 100
• Forme: powder
• Couleur: yellow
• Solubilité: DMSO: 2 mg/mL, clear (warmed)
• Auteur: Novartis
• Température de stockage: room temp
• Chaîne SMILES: CCCCN(CCCC)CC(O)c1cc(Cl)cc2C(=C/c3ccc(Cl)cc3)\c4cc(Cl)ccc4-c12
• InChI: 1S/C30H32Cl3NO/c1-3-5-13-34(14-6-4-2)19-29(35)28-18-23(33)17-27-25(15-20-7-9-21(31)10-8-20)26-16-22(32)11-12-24(26)30(27)28/h7-12,15-18,29,35H,3-6,13-14,19H2,1-2H3/b25-15-
• Clé InChI: DYLGFOYVTXJFJP-MYYYXRDXSA-N

Description

Description générale

Lumefantrine, also known as benflumetol is an aryl-amino alcohol. It is a member of the group of arylamine alcohols like quinine, mefloquine and halofantrine.

Application

Lumefantrine has been used:
to study its effect on ex-vivo Plasmodium falciparum sensitivity using the tritiated hypoxanthine-based assay
as a standard in the quantification of combined tablet formulation using HPTLC
as a drug molecule in in vitro growth inhibition assay for in vitro B. caballi growth inhibition studies

Actions biochimiques/physiologiques

Lumefantrine is is an antimalarial for the treatment of multi-drug resistant strains of falciparum malaria.

Caractéristiques et avantages

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable