92360

Chlorotrimethylsilane

puriss., ≥99.0% (GC)

• Synonyme(s) : TMCS, Trimethylchlorosilane, Trimethylsilyl chloride
• Formule linéaire : (CH₃)₃SiCl
• Numéro CAS: 75-77-4
• Poids moléculaire : 108.64
• Numéro Beilstein : 1209232
• Numéro CE : 200-900-5
• Numéro MDL: MFCD00000502
• Code UNSPSC : 12352101
• ID de substance PubChem : 329770119
• Nomenclature NACRES : NA.22

Propriétés

• Densité de vapeur: 3.7 (vs air)
• Niveau de qualité: 200
• Pression de vapeur: 100 mmHg ( 25 °C)
• Qualité: puriss.
• Pureté: ≥99.0% (GC)
• Forme: liquid
• Température d'inflammation spontanée: 752 °F
• Limite d'explosivité: 6.4 %
• Indice de réfraction: n20/D 1.387 (lit.)
• Point d'ébullition: 57 °C (lit.)
• Pf: −40 °C (lit.)
• Densité: 0.856 g/mL at 25 °C (lit.)
• Chaîne SMILES: C[Si](C)(C)Cl
• InChI: 1S/C3H9ClSi/c1-5(2,3)4/h1-3H3
• Clé InChI: IJOOHPMOJXWVHK-UHFFFAOYSA-N

Description

Description générale

Chlorotrimethylsilane is a chloro-organosilane compound mainly used for silylation reactions.

Application

• Chlorotrimethylsilane can be a non-toxic alternative to mercuric chloride as activator in samarium-promoted cyclopropanation of both allylic and α-allenic alcohols.
• It can be used in combination with hexamethyldisilazane for the protection of alcohols by forming trimethylsilyl ethers via silylation.
• It is employed in chloromethylation of polysulfones (PSUs).
• It activates lithium hydride to convert it into a hydride source for the reductive silylation of carbonyl compounds.
• Chlorotrimethylsilane/lithium bromide forms an effective reagent for the conversion of alcohols to bromides.
• Chlorotrimethylsilane/sodium iodide in acetonitrile is a better alternative to iodotrimethylsilane for the cleavage of esters, lactones, carbamates, and ethers. It can also be used for the conversion of alcohols to iodides.
• Chlorotrimethylsilane along with silver or ammonium nitrate forms an efficient regioselective nitrating reagent for the ipso-nitration of arylboronic acids to form the corresponding nitroarenes.
• Chlorotrimethylsilane along with sodium nitrite or nitrate can be used for deoximation reactions.

Autres remarques

Agent de silylation

Informations sur la sécurité

• Pictogrammes: GHS02,GHS06,GHS05
• Mention d'avertissement: Danger
• Mentions de danger: H225,H301 + H331,H312,H314
• Conseils de prudence: P210 - P233 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• Classification des risques: Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Acute Tox. 4 Dermal - Eye Dam. 1 - Flam. Liq. 2 - Skin Corr. 1A
• Risques supp: EUH014
• Code de la classe de stockage: 3 - Flammable liquids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): -18.4 °F - closed cup
• Point d'éclair (°C): -28 °C - closed cup
• Équipement de protection individuelle: Faceshields, Gloves, Goggles