52619

Hexaméthyldisilazane

for GC derivatization, LiChropur^™, ≥99.0% (GC)

• Synonyme(s) : HMDS
• Formule linéaire : (CH₃)₃SiNHSi(CH₃)₃
• Numéro CAS: 999-97-3
• Poids moléculaire : 161.39
• Numéro Beilstein : 635752
• Numéro CE : 213-668-5
• Numéro MDL: MFCD00008259
• Code UNSPSC : 12000000
• ID de substance PubChem : 329757861
• Nomenclature NACRES : NA.22

Propriétés

• Qualité: for GC derivatization; LiChropur^™
• Niveau de qualité: 100
• Pureté: ≥99.0% (GC)
• Forme: liquid
• Pertinence de la réaction: reagent type: derivatization reagent; reaction type: Silylations
• Technique(s): gas chromatography (GC): suitable
• Indice de réfraction: n20/D 1.407 (lit.); n20/D 1.408
• Point d'ébullition: 125 °C (lit.)
• Chaîne SMILES: C[Si](C)(C)N[Si](C)(C)C
• InChI: 1S/C6H19NSi2/c1-8(2,3)7-9(4,5)6/h7H,1-6H3
• Clé InChI: FFUAGWLWBBFQJT-UHFFFAOYSA-N

Description

Description générale

Hexamethyldisilazane (HMDS) is a commercially available, silylating agent, which is used as an alternative for the preparation of silyl ethers from hydroxyl compounds.

Application

Learn more in the Product Information

Hexamethyldisilazane is suitable for the derivatization of alcohols, U-aminobutyric acid, pesticidal carbamates and urea, 3,4-Dihydroxyphenylglycol, 4-hydroxycoumarins, hydroxyfatty acids, n-hydroxy-2-fluorenylacetamide, kerb cycle acid, malonaldehyde, monoglycerides, phenylpyruvic acid, shikimic acid, unsaturated fatty acid esters (or methyl esters), and related compounds.

It may be used as a derivatizing reagent for the analysis of bioamines and their acidic metabolites, phenol, hydroquinone and catechol in urine samples, mixtures of free fatty acids and metal soaps in paint samples using gas chromatography/mass spectrometry (GC/MS).

Suitable for the derivatization of alcohols, Υ-aminobutyric acid, pesticidal carbamates and urea, 3,4-Dihydroxyphenylglycol, 4-hydroxycoumarins, hydroxyfatty acids, n-hydroxy-2-fluorenylacetamide, kerb cycle acid, malonaldehyde, monoglycerides, phenylpyruvic acid, shikimic acid, unsaturated fatty acid esters (or methyl esters), and related compounds.

Caractéristiques et avantages

• HMDS is inexpensive and has a relatively low boiling point (124-127 °C).        
• It can be used without solvent but its silylating power can be increased by various (mostly acidic) catalysts.        
• The only reaction byproduct, ammonia, can leave the reaction mixture as the reaction goes to completion.

Autres remarques

Agent de silylation important

Reagent for 2-hydroxypyrimidine, polytrimethylsilyloxy, trimethylsilyl and trimethylsilyl oximes.

Informations légales

LiChropur is a trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Pictogrammes: GHS02,GHS06
• Mention d'avertissement: Danger
• Mentions de danger: H225,H302 + H332,H311,H412
• Conseils de prudence: P210 - P273 - P280 - P301 + P312 - P303 + P361 + P353 - P304 + P340 + P312
• Classification des risques: Acute Tox. 3 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Flam. Liq. 2
• Code de la classe de stockage: 3 - Flammable liquids
• Classe de danger pour l'eau (WGK): WGK 2
• Point d'éclair (°F): 52.5 °F - closed cup
• Point d'éclair (°C): 11.4 °C - closed cup
• Équipement de protection individuelle: Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter