917109

2-(3-(1-(tert-butoxycarbonyl)piperidin-4-yl)phenyl)acetic acid

• Synonyme(s) : Semi-flexible linker for PROTAC^® development
• Formule empirique (notation de Hill): C₁₈H₂₅NO₄
• Numéro CAS: 1801176-81-7
• Poids moléculaire : 319.40
• Code UNSPSC : 12352106

Propriétés

• Forme: powder
• Niveau de qualité: 100
• Pertinence de la réaction: reagent type: linker
• Groupe fonctionnel: Boc; carboxylic acid
• Température de stockage: 2-8°C
• Chaîne SMILES: O=C(N(CC1)CCC1C2=CC(CC(O)=O)=CC=C2)OC(C)(C)C

Description

Application

2-(3-(1-(tert-Butoxycarbonyl)piperidin-4-yl)phenyl)acetic acid is a 4-aryl piperidine useful as a semi-flexible linker in PROTAC development for targeted protein degradation. Incorporation of rigidity into the linker region of bifunctional protein degraders may impact the 3D orientation of the degrader and thus ternary complex formation as well as optimization of drug-like properties.

Autres remarques

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Crosslinkers for Bioconjugation

Portal: Building PROTAC^® Degraders for Targeted Protein Degradation

Informations légales

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Informations sur la sécurité

• Pictogrammes: GHS07,GHS09
• Mention d'avertissement: Warning
• Mentions de danger: H315,H317,H319,H410
• Conseils de prudence: P261 - P264 - P273 - P280 - P302 + P352 - P305 + P351 + P338
• Classification des risques: Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable