42251
Apigenin
analytical standard
Synonyme(s) :
4′,5,7-Trihydroxyflavone, 5,7-Dihydroxy-2-(4-hydroxyphenyl)-4-benzopyrone
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About This Item
Formule empirique (notation de Hill):
C15H10O5
Numéro CAS:
Poids moléculaire :
270.24
Numéro Beilstein :
262620
Numéro CE :
Numéro MDL:
Code UNSPSC :
85151701
ID de substance PubChem :
Nomenclature NACRES :
NA.24
Produits recommandés
Qualité
analytical standard
Niveau de qualité
Pureté
≥99% (HPLC)
Durée de conservation
limited shelf life, expiry date on the label
Technique(s)
HPLC: suitable
gas chromatography (GC): suitable
Pf
>300 °C (lit.)
Application(s)
food and beverages
Format
neat
Température de stockage
2-8°C
Chaîne SMILES
Oc1ccc(cc1)C2=CC(=O)c3c(O)cc(O)cc3O2
InChI
1S/C15H10O5/c16-9-3-1-8(2-4-9)13-7-12(19)15-11(18)5-10(17)6-14(15)20-13/h1-7,16-18H
Clé InChI
KZNIFHPLKGYRTM-UHFFFAOYSA-N
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Description générale
Flavonoids belong to polyphenolic class of compounds. They play crucial role in biological activities which include tumor growth inhibition and chemoprevention. Apigenin is a plant flavonoid mostly used to inhibit ornithine decarboxylase activity and skin tumor.
Apigenin can be found in a wide range of medicinal plants such as Achillea sp., Chamomilla sp., Equisetum sp., Mentha sp., Salix sp., Salvia sp., Silybum sp., Thymus sp., Verbascum sp.
Apigenin can be found in a wide range of medicinal plants such as Achillea sp., Chamomilla sp., Equisetum sp., Mentha sp., Salix sp., Salvia sp., Silybum sp., Thymus sp., Verbascum sp.
Application
It may be used as internal standard for determining peurarin and its metabolites, using LC-ESI-MS/MS, in blood and urine of rats.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Actions biochimiques/physiologiques
A plant flavonoid that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. Inhibition of growth through cell cycle arrest and induction of apoptosis appear to be related to induction of p53. Inhibits PMA-mediated tumor promotion by inhibiting protein kinase C and the resulting suppression of oncogene expression. It has also been reported to inhibit topoisomerase I-catalyzed DNA re-ligation and enhance gap junctional intercellular communication.
Conditionnement
Bottomless glass bottle. Contents are inside inserted fused cone.
Autres remarques
This compound is commonly found in plants of the genus: achillea mentha pimpinella primula salvia silybum thymus
Code de la classe de stockage
11 - Combustible Solids
Classe de danger pour l'eau (WGK)
WGK 3
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The purpose of this study was to investigate the anti-inflammatory potential of the natural flavonoid apigenin to mitigate the airway inflammation in asthmatic mice exposed to particulate matter (PM) 2.5, and examine the possible mechanisms involved. BALB/c mice were sensitized
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