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05238

Supelco

Erythromycin-A-enolether

analytical standard

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About This Item

Formule empirique (notation de Hill):
C37H65NO12
Numéro CAS:
33396-29-1
Poids moléculaire :
715.91
Code UNSPSC :
41116107
Nomenclature NACRES :
NA.24

Qualité

analytical standard

Niveau de qualité

100

Pureté

≥95% (HPLC)

Durée de conservation

limited shelf life, expiry date on the label

Technique(s)

HPLC: suitable
gas chromatography (GC): suitable

Application(s)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

Format

neat

Chaîne SMILES 

CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@@H](C3O)N(C)C)[C@@]4(C)CC(C)=C(O4)[C@H](C)[C@@H](O)[C@]1(C)O

InChI

1S/C37H65NO12/c1-14-25-37(10,43)30(40)20(4)28-18(2)16-36(9,50-28)32(49-34-27(39)24(38(11)12)15-19(3)45-34)21(5)29(22(6)33(42)47-25)48-26-17-35(8,44-13)31(41)23(7)46-26/h19-27,29-32,34,39-41,43H,14-17H2,1-13H3/t19-,20+,21+,22-,23+,24+,25-,26+,27-,29+,30-,31+,32-,34+,35-,36-,37-/m1/s1

Clé InChI

JFVYXJKGJMUGRG-KJPZRSJGSA-N

Description générale

Erythromycin A enol ether (EAEN) is an acidic degradation product of erythromycin A (EA) which is grouped under the macrolide antibiotic class of compounds.

Application

EAEN has been used for the analysis of EAEN as degradation product of EA in honey by ultra-performance liquid chromatography equipped with tandem quadrupole mass spectrometer (UPLC-MS/MS) with positive electrospray ionisation (ESI) operating on multiple reaction monitoring (MRM) mode and in rat′s blood plasma, serum and human urine by high performance liquid chromatography-coulometric assay. It may be used as a reference standard for the detection of EAEN in erythromycin fractions by isocratic LC with evaporative light scattering detection (ELSD) and ion trap MS and in commercial erythromycin samples by LC-MS/MS.

Conditionnement

Bottomless glass bottle. Contents are inside inserted fused cone.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

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Certificats d'analyse (COA)

Lot/Batch Number
BCCL0372
BCCF0025
BCBZ4501
BCBW1058
BCBT9997

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Consulter la Bibliothèque de documents

H Monji et al.
Journal of chromatography. B, Biomedical sciences and applications, 690(1-2), 305-313 (1997-03-07)
A method for the simultaneous determination of de(N-methyl)-N-ethyl-8,9 -anhydroerythromycin A 6,9-hemiacetal (EM523, I) and its three metabolites in human plasma and urine has been developed using high-performance liquid chromatography (HPLC) with chemiluminescence (CL) detection. Plasma and urine samples spiked with
N Inatomi et al.
Japanese journal of pharmacology, 63(2), 209-217 (1993-10-01)
The effect of EM523 [de(N-methyl)-N-ethyl-8,9-anhydroerythromycin A 6,9-hemiacetal], an erythromycin derivative, on gastrointestinal motility was investigated using conscious dogs in the fasting state, and it was compared with those of motilin and prostaglandin F2 alpha (PGF2 alpha). EM523 and motilin given
Development of an enhanced separation of erythromycin and its related substances by liquid chromatography.
Deubel A and Holzgrabe U
Journal of Pharmaceutical and Biomedical Analysis, 43(2), 493-498 (2007)
T Nakamura et al.
Clinical therapeutics, 16(6), 989-999 (1994-11-01)
EM523L, a newly developed erythromycin derivative, has a powerful motilin-like biologic effect and no antibacterial activity. In this pilot study, EM523L was administered to six patients with diabetic gastroparesis, and its effects on gastric emptying function and the change in
M Ohtawa et al.
Gastroenterology, 104(5), 1320-1327 (1993-05-01)
The pharmacological properties of EM523, a nonpeptide motilin agonist, have not been well characterized. The prokinetic effect of EM523 on motor-stimulating activity in the stomach, duodenum, and jejunum in seventeen conscious dogs was studied using force transducers implanted long term.
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