MABN92-AF555

Anti-Iba1/AIF1 Antibody, clone 20A12.1, Alexa Fluor^™ 555 Conjugate

clone 20A12.1, from mouse, ALEXA FLUOR^™ 555

• Synonyme(s) : Allograft inflammatory factor 1, AIF-1, Daintain, Interferon gamma responsive transcript, Ionized calcium-binding adapter molecule 1, Protein G1
• Code UNSPSC : 12352203
• eCl@ss : 32160702
• Nomenclature NACRES : NA.45

Propriétés

• Source biologique: mouse
• Niveau de qualité: 100
• Conjugué: ALEXA FLUOR^™ 555
• Forme d'anticorps: purified antibody
• Type de produit anticorps: primary antibodies
• Clone: 20A12.1, monoclonal
• Espèces réactives: rat, mouse, human
• Technique(s): immunohistochemistry: suitable
• Isotype: IgG1κ
• Numéro d'accès NCBI: NP_001614
• Numéro d'accès UniProt: P55008
• Conditions d'expédition: wet ice
• Modification post-traductionnelle de la cible: unmodified
• Informations sur le gène: human ... AIF1(199)

Description

Description générale

Allograft inflammatory factor 1 (UniProt P55008; also known as AIF-1, Daintain, Interferon gamma responsive transcript, Ionized calcium-binding adapter molecule 1, Protein G1) is encoded by the AIF1 (also known as G1, IBA1) gene (Gene ID 199) in human. Iba1/AIF1 is a 17 kDa interferon-gamma- (IFN-gamma-) inducible, Ca(2+)-binding EF-hand protein. Iba1/AIF1 expression is mostly limited to the macrophage/monocyte lineage, and is augmented by cytokines, such as IFN-gamma. It is reported to be involved in neuronal function, inflammatory responses, allograft rejection, autoimmunity, and macrophage activation/function. It is also shown to be expressed in microglial cells in autominnume disesase models such as experimental autoimmune encephalomyelitis, neuritis and uveitis.

Immunogène

Linear peptide corresponding to a human Iba1/AIF1 sequence.

Application

Anti-Iba1/AIF1 Antibody, clone 20A12.1, Alexa Fluor^™ 555 Conjugate is an antibody against Iba1/AIF1 for use in Immunohistochemistry.

Research Category
Neuroscience

Research Sub Category
Developmental Neuroscience

The unconjugated antibody (Cat. No. MABN92) is shown to be suitable also for Western blotting and immunohistochemistry applications.

Qualité

Evaluated by Immunohistochemistry in human spleen tissue.

Immunohistochemistry Analysis: A 1:150 dilution of this antibody detected Iba1/AIF1 in human spleen tissue.

Description de la cible

~17 kDa observed

Forme physique

Protein G Purified

Purified mouse antibody conjugate in PBS with 15 mg/mL BSA and 0.1 % sodium azide.

Stockage et stabilité

Stable for 1 year at 2-8°C from date of receipt.

Autres remarques

Concentration: Please refer to lot specific datasheet.

Informations légales

ALEXA FLUOR is a trademark of Life Technologies

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 2
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable