ABS535
Anti-Arginase-1 Antibody
from chicken
Synonyme(s) :
Type 1 Arginase
ARG1
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About This Item
Code UNSPSC :
12352203
eCl@ss :
32160702
Nomenclature NACRES :
NA.41
Produits recommandés
Source biologique
chicken
Niveau de qualité
Forme d'anticorps
purified immunoglobulin
Type de produit anticorps
primary antibodies
Clone
polyclonal
Espèces réactives
guinea pig, human, mouse, rat
Technique(s)
immunohistochemistry: suitable
western blot: suitable
Isotype
IgY
Numéro d'accès NCBI
Numéro d'accès UniProt
Conditions d'expédition
wet ice
Modification post-traductionnelle de la cible
unmodified
Informations sur le gène
human ... ARG1(383)
mouse ... Arg1(11846)
rat ... Arg1(29221)
Description générale
Arginase-1, the protein encoded by the ARG1 gene, is the enzyme that catalyzes the breakdown of L-arginine into ornithine and urea. ARG1 is a key player in the Urea cycle. There are two distinct isoforms of Arginase, Arginase I and Arginase II. Arginase I (also called the liver type arginase or Type 1 arginase) is a highly expressed cytosolic enzyme in the liver and other tissues, including the brain. Arginase II or kidney-type arginase is also widely expressed at low levels in many tissues but localized to the mitochondria primarily. Interestingly, Arginase 1 has neuroprotective properties. Arginase I is essential for protecting motor neurons from nitric oxide dependent apoptosis that can be induced upon cellular stress or trophic factor removal. By suppressing nitric oxide production, Arginase prevents the formation of peroxynitrite and its subsequent cellular toxicity. Furthermore, Arginase 1 appears to play critical roles throughout the CNS for survival and regeneration of neurons and axons. In cancer, Arginase 1, already a useful marker for hepatocytes is also an excellent marker for hepatocellular cancers.
Immunogène
Full-length recombinant protein corresponding to Rat Arginase-1.
Application
Analyse par immunohistochimie : A representative lot detected Arginase-1 in bronchoalveolar lavage cells (Zimmermann, N., et al. (2003). –
A representative lot detected Arginase-1 in RAW cell lysate (Morris, S., et al. (1998). Am J Physiol Endocrinol Metab 275:E740-E747, 1998).
A representative lot detected Arginase-1 in RAW cell lysate (Morris, S., et al. (1998). Am J Physiol Endocrinol Metab 275:E740-E747, 1998).
Domaine de recherche
Signalisation
Signalisation
This Anti-Arginase-1 Antibody is validated for use in Western Blotting and Immunohistochemistry for the detection of Arginase-1.
Qualité
µµ
Description de la cible
Poids réel (observé) : env. 38 kDa
Forme physique
Format : Produit purifié
IgY purified from Yolk
Purified chicken Polyclonal other in buffer containing PBS with 0.05% sodium azide.
Stockage et stabilité
Stable entre 2 et 8 °C pendant 1 an à compter de la date de réception.
Autres remarques
Concentration : Voir la fiche technique du lot concerné.
Clause de non-responsabilité
Sauf indication contraire dans notre catalogue ou toute autre documentation associée au(x) produit(s), nos produits sont uniquement destinés à la recherche et ne sauraient être utilisés à d'autres fins, ce qui inclut, sans s'y limiter, les utilisations commerciales non autorisées, les utilisations diagnostiques in vitro, les utilisations thérapeutiques ex vivo ou in vivo, ou tout type de consommation ou d'application chez l'être humain ou chez l'animal.
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Code de la classe de stockage
12 - Non Combustible Liquids
Classe de danger pour l'eau (WGK)
WGK 2
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Certificats d'analyse (COA)
Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".
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