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Key Documents

ABN278

Sigma-Aldrich

Anti-Prospero homeobox protein 1/PROX1 Antibody

from rabbit, purified by affinity chromatography

Synonyme(s) :

Prospero homeobox protein 1, Homeobox prospero-like protein PROX1, PROX-1

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About This Item

Code UNSPSC :
12352203
eCl@ss :
32160702
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Niveau de qualité

100

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Produit purifié par

affinity chromatography

Espèces réactives

mouse, rat

Réactivité de l'espèce (prédite par homologie)

bovine (based on 100% sequence homology), fish (based on 100% sequence homology), chicken (based on 100% sequence homology), human (based on 100% sequence homology)

Technique(s)

immunohistochemistry: suitable
western blot: suitable

Numéro d'accès NCBI

NP_001257545

Numéro d'accès UniProt

Q92786

Conditions d'expédition

wet ice

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

mouse ... Prox1(19130)

Description générale

PROX1 (Prospero homeobox protein 1), the homolog of Drosophila Prospero, is a homeobox-containing transcription factor that binds and functions as a co-receptor of liver receptor homolog 1 (LRH1/NR5A2). It is a specific marker for lymphatic endothelial cells, as well as hepatoblasts and hepatocytes. Human Prox1 shares 97% amino acid sequence identity with mouse and rat Prox1.

Immunogène

KLH-conjugated linear peptide corresponding to the C-terminus of human Prospero homeobox protein 1/PROX1.

Application

Immunohistochemistry Analysis: A 1:2,000 dilution from a representative lot detected Prospero homeobox protein 1/PROX1 in mouse E16 embryo thalamus tissues (Prof. Samual Pleasure, University of California, San Francisco.).

Alexa Fluor™ is a registered trademark of Life Technologies, Inc.
This Anti-Prospero homeobox protein 1/PROX1 Antibody is validated for use in western blotting & IHC for the detection of Prospero homeobox protein 1/PROX1.

Qualité

Evaluated by Western Blotting in HEK293 nuclear extract.

Western Blotting Analysis: A 1:500 dilution of this antibody detected Prospero homeobox protein 1/PROX1 in 10 µg of HEK293 nuclear extract.

Description de la cible

~95 kDa observed. Uniprot describes a molecular weight at 83 kDa However, this protein may be observed between 80-110 kDa due to sumoylation and/or alternative start sites (Pan, M. R., et al. (2009). J Cell Sci. 122(Pt18):3358-3361.; Azuma, K., et al. (2011). Genes Cells. 16(11):1063-1070.).

Liaison

Replaces: AB5475

Informations légales

ALEXA FLUOR is a trademark of Life Technologies

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Réf. du produit
Description
Tarif

Code de la classe de stockage

12 - Non Combustible Liquids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Charlotte M Ermine et al.
Journal of neuroscience research, 99(12), 3222-3237 (2021-10-16)
Animal modeling has played an important role in our understanding of the pathobiology of stroke. The vast majority of this research has focused on the acute phase following severe forms of stroke that result in clear behavioral deficits. Human stroke
Charlotte M Ermine et al.
Hippocampus, 28(5), 327-337 (2018-02-13)
Key pathological features of Parkinson's Disease (PD) include the progressive degeneration of midbrain dopaminergic (DA) neurons and hindbrain noradrenergic (NA) neurons. The loss of DA neurons has been extensively studied and is the main cause of motor dysfunction. Importantly, however
Lu M Yang et al.
PLoS genetics, 15(7), e1008254-e1008254 (2019-07-06)
The mouse organ of Corti, housed inside the cochlea, contains hair cells and supporting cells that transduce sound into electrical signals. These cells develop in two main steps: progenitor specification followed by differentiation. Fibroblast Growth Factor (FGF) signaling is important
Hidenori Ito et al.
Hippocampus, 29(7), 569-578 (2018-11-06)
The hippocampus is generally considered as a brain center for learning and memory. We have recently established an electroporation-mediated gene transfer method to investigate the development of neonatal dentate granule cells in vivo. Using this new technique, we introduced knockdown
In-Young Choi et al.
Frontiers in molecular neuroscience, 15, 917598-917598 (2022-07-26)
Anxiety disorder is one of the most common comorbidities in temporal lobe epilepsy (TLE), but its neurobiological mechanisms remain unclear. Here we identified a novel target, interleukin-17A (IL-17A), which can contribute to TLE-associated anxiety. Epileptic seizures were induced in 6-week-old
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