AB5060
Anti-Substance P Receptor Antibody, pain
serum, Chemicon®
Synonyme(s) :
NK-1 Receptor
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About This Item
Code UNSPSC :
12352203
eCl@ss :
32160702
Nomenclature NACRES :
NA.41
Produits recommandés
Source biologique
rabbit
Niveau de qualité
Forme d'anticorps
serum
Type de produit anticorps
primary antibodies
Clone
polyclonal
Espèces réactives
rat, guinea pig, mouse
Fabricant/nom de marque
Chemicon®
Technique(s)
immunofluorescence: suitable
immunohistochemistry: suitable
western blot: suitable
Numéro d'accès NCBI
Numéro d'accès UniProt
Conditions d'expédition
dry ice
Modification post-traductionnelle de la cible
unmodified
Informations sur le gène
human ... TAC1(6863)
Description générale
Substance P is a tachykinin family neuropeptide that functions as a neurotransmitter and neuromodulator. In the CNS, Substance P is involved in the regulation of mood, anxiety, sleep, saiety, reinforcement, respiratory rhythm and pain processing. In nociception, the neuropeptide is released at local spinal cord synapses. Recent research now shows substance P is potentially involved in endothelial cell differentiation as well as diverse roles in neuroinflammatory response. The endogenous receptor for Substance P is neurokinin 1 receptor (NK1 receptor), which belongs to the tachykinin receptor sub-family of GPCRs.
Spécificité
Specific for the Substance P Receptor (NK-1).
Immunogène
Epitope: C terminus
Synthetic peptide that corresponds to a 23 amino acid sequence (385-407) of the COOH terminus of the rat Substance P Receptor (NK-1).
Application
Anti-Substance P Receptor Antibody, pain detects level of Substance P Receptor & has been published & validated for use in IF, IH & WB.
Immunohistochemistry:
A previous lot was used at 1:100-1:1,000 dilution.
Western Blot Analysis:
A previous lot was used at 1:500 dilution.
Optimal working dilutions must be determined by the end user.
A previous lot was used at 1:100-1:1,000 dilution.
Western Blot Analysis:
A previous lot was used at 1:500 dilution.
Optimal working dilutions must be determined by the end user.
Research Category
Neuroscience
Neuroscience
Research Sub Category
Neuroinflammation & Pain
Neuroinflammation & Pain
Qualité
Evaluated by western blot on Mouse brain membrane lysates.
Western Blot Analysis:
1:500 dilution of this antibody detected NK-1R on 10 μg of Mouse brain membrane lysates.
Western Blot Analysis:
1:500 dilution of this antibody detected NK-1R on 10 μg of Mouse brain membrane lysates.
Description de la cible
35 kDa
Liaison
Replaces: AB5800
Forme physique
Rabbit polyclonal serum containing no preservative.
Unpurified
Stockage et stabilité
Stable for 1 year at -20ºC from date of receipt.
Remarque sur l'analyse
Control
Spinal Cord, brain membrane lysate
Spinal Cord, brain membrane lysate
Autres remarques
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Informations légales
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Clause de non-responsabilité
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Réf. du produit
Description
Tarif
Code de la classe de stockage
11 - Combustible Solids
Classe de danger pour l'eau (WGK)
WGK 1
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Certificats d'analyse (COA)
Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".
Déjà en possession de ce produit ?
Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.
Terminal field and firing selectivity of cholecystokinin-expressing interneurons in the hippocampal CA3 area.
Lasztoczi, B; Tukker, JJ; Somogyi, P; Klausberger, T
The Journal of Neuroscience null
Yanyan Zhang et al.
International journal of oral science, 11(3), 24-24 (2019-09-11)
Inflammatory orofacial pain, in which substance P (SP) plays an important role, is closely related to the cross-talk between trigeminal ganglion (TG) neurons and satellite glial cells (SGCs). SGC activation is emerging as the key mechanism underlying inflammatory pain through
L Sosulina et al.
Journal of neurophysiology, 114(4), 2500-2508 (2015-09-04)
Substance P (SP) is implicated in stress regulation and affective and anxiety-related behavior. Particularly high expression has been found in the main output region of the amygdala complex, the central amygdala (CE). Here we investigated the cellular mechanisms of SP
Wenling Chen et al.
Neuropharmacology, 128, 255-268 (2017-10-19)
The interaction between NMDA receptors and μ-opioid receptors in primary afferent terminals was studied by using NMDA to induce substance P release, measured as neurokinin 1 receptor internalization. In rat spinal cord slices, the μ-opioid receptor agonists morphine, DAMGO and
Amie Severino et al.
Pain, 159(8), 1607-1620 (2018-04-21)
The latent sensitization model of chronic pain reveals that recovery from some types of long-term hyperalgesia is an altered state in which nociceptive sensitization persists but is suppressed by the ongoing activity of analgesic receptors such as μ-opioid receptors (MORs).
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