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8.55134

Sigma-Aldrich

Ramage Amide AM resin

Novabiochem®

Synonyme(s) :

2-{[(R,S)-5-(9-Fluorenylmethyloxycarbonyl-amino)-10,11-dihydro-5H-dibenzo[a,d]cycloheptene-2-yl]oxy}acetyl-AM resin

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About This Item

Code UNSPSC :
12352111
Nomenclature NACRES :
NA.22

Niveau de qualité

200

Gamme de produits

Novabiochem®

Forme

beads

Capacité de réaction

reaction type: Fmoc solid-phase peptide synthesis

Fabricant/nom de marque

Novabiochem®

Application(s)

peptide synthesis

Groupe fonctionnel

amine

Température de stockage

2-8°C

Description générale

Ramage Amide AM resin comprises Ramage′s dibenzocycloheptadienelinker [1] attached to aminomethylated polystyrene. Following Fmoc removal, the resin can be acylated under standard conditions and used in Fmoc SPPS. The linker is considerably more acid sensitive than the Rink amide or PAL linkers. This enables peptide amides to be released from the resin with 3% TFA in DCM and thus makes it a useful tool for the synthesis of acid sensitive peptides or protected peptide fragments.


Associated Protocols and Technical Articles
Protocols for Loading of Peptide Synthesis Resins

Literature references

[1] R. Ramage, et al. (1993) Tetrahedron Lett., 34, 6599.

Remarque sur l'analyse

Colour (visual): white to yellow to beige
Appearance of substance (visual): beads
Loading (Photometric determination of the Fmoc-chromophore liberated upon treatment with DBU/DMF): 0.40 - 0.80 mmol/g
Swelling Volume (in DMF): lot specific result

Informations légales

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Articles

Fmoc SPPS Linkers

Novabiochem® offers a wide range of linkers and derivatized resins for Fmoc solid-phase peptide synthesis with specialized protocols.

Fmoc SPPS Linkers

Novabiochem® offers a wide range of linkers and derivatized resins for Fmoc solid-phase peptide synthesis with specialized protocols.

Fmoc SPPS Linkers

Novabiochem® offers a wide range of linkers and derivatized resins for Fmoc solid-phase peptide synthesis with specialized protocols.

Fmoc SPPS Linkers

Novabiochem® offers a wide range of linkers and derivatized resins for Fmoc solid-phase peptide synthesis with specialized protocols.

Protocoles

Peptide Resin Loading Protocols

Review various resins like Merrifield, trityl-based, and hydroxymethyl-functionalized for peptide immobilization for diverse applications.

Peptide Resin Loading Protocols

Review various resins like Merrifield, trityl-based, and hydroxymethyl-functionalized for peptide immobilization for diverse applications.

Peptide Resin Loading Protocols

Review various resins like Merrifield, trityl-based, and hydroxymethyl-functionalized for peptide immobilization for diverse applications.

Peptide Resin Loading Protocols

Review various resins like Merrifield, trityl-based, and hydroxymethyl-functionalized for peptide immobilization for diverse applications.

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