8.55003

Rink Amide MBHA resin (100-200 mesh)

Novabiochem^®

• Synonyme(s) : Rink Amide MBHA resin (100-200 mesh), 4-(2′,4′-Dimethoxyphenyl-Fmoc-aminomethyl)-phenoxyacetamido-norleucyl-MBHA resin (100-200 mesh)
• Numéro CAS: 431041-83-7
• Code UNSPSC : 12352111
• Nomenclature NACRES : NA.22

Propriétés

• Niveau de qualité: 400
• Gamme de produits: Novabiochem^®
• Forme: beads
• Capacité de réaction: reaction type: Fmoc solid-phase peptide synthesis
• Fabricant/nom de marque: Novabiochem^®
• Application(s): peptide synthesis
• Groupe fonctionnel: amine
• Température de stockage: 2-30°C

Description

Description générale

This support comprises the modified Rink amide linker attached via norleucine to MBHA resin, and is an ideal tool for the Fmoc SPPS of peptide amides. Cleavage from this resin can be effected by a single step treatment with 95% TFA, providing peptide amides in high yields and purities.

Associated Protocols and Technical Articles
Protocols for Loading of Peptide Synthesis Resins

Application

• Liquid chromatography-tandem mass spectrometry for forensic analysis: LSD-D₃ is utilized as an internal standard in the liquid chromatography-tandem mass spectrometry determination of LSD and its metabolites in forensic samples, enhancing accuracy and precision in the analytical results (Johansen and Jensen, 2005).


• Isotope dilution mass spectrometry in urine testing: Employed in the high-performance liquid chromatography-isotope dilution mass spectrometry (IDMS) method, LSD-D₃ serves as a crucial internal standard for the quantification of lysergide (LSD) in urine, aiding in precise and accurate drug testing (White et al., 1999).


• Automated extraction and LC/MS/MS confirmation: LSD-D₃ is used in the automated extraction of lysergic acid diethylamide from various biological matrices, followed by confirmation using LC/MS/MS. This application highlights its role in improving the efficiency and reliability of toxicological analyses (de Kanel et al., 1998).

Liaison

Replaces: 01-64-0037

Remarque sur l'analyse

Colour (visual): white to light yellow to beige
Appearance of substance (visual): beads
Loading (Photometric determination of the Fmoc-chromophore liberated upon treatment with DBU/DMF): 0.40 - 0.90 mmol/g
TNBS-Test: passes test
Swelling Volume (in DMF): lot specific result
Swelling Volume (in CH₂Cl₂): lot specific result
Total swelling volume acc. Houben Weyl (in CH₂Cl₂): ≥ 5.2 ml/g
Total swelling volume acc. Houben Weyl (in DMF): ≥ 5.2 ml/g
The polymer matrix is copoly (styrene-1 % DVB), 100 -200 mesh.

Informations légales

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable