8.51061

2-Chlorotrityl chloride

Novabiochem^®

• Synonyme(s) : 2-Chlorotrityl chloride
• Formule empirique (notation de Hill): C₁₉H₁₄Cl₂
• Numéro CAS: 42074-68-0
• Poids moléculaire : 313.22
• Numéro MDL: MFCD00040399
• Code UNSPSC : 12352107
• Numéro de classement CE : 255-647-3
• Nomenclature NACRES : NA.22

Propriétés

• Niveau de qualité: 200
• Gamme de produits: Novabiochem^®
• Pureté: ≥95.0% (HPLC)
• Forme: powder
• Fabricant/nom de marque: Novabiochem^®
• Pf: 133.0-137.0 °C
• Application(s): peptide synthesis
• Température de stockage: 2-30°C
• InChI: 1S/C19H14Cl2/c20-18-14-8-7-13-17(18)19(21,15-9-3-1-4-10-15)16-11-5-2-6-12-16/h1-14H
• Clé InChI: JFLSOKIMYBSASW-UHFFFAOYSA-N

Description

Description générale

Hyperacid-labile ester protecting group ^[1]. Introduced under extremely mild conditions by reacting together the acid, trityl chloride and DIPEA in DCM. Ideal for the protection of the C-terminal carboxylic acid group of C-terminal protected peptide fragments, monoprotection of diacids and as a general carboxylic acid protecting group in organic synthesis.


Associated Protocols and Technical Articles
Guide to Selection of Orthogonally-Protected Building Blocks for Fmoc SPPS

Literature references

^[1] P. Athanassopoulos, et al. (1995) Tetrahedron Lett., 36, 5645.

Liaison

Replaces: 01-63-0045

Remarque sur l'analyse

Color (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Melting range (lower value): ≥ 133 °C
Melting range (upper value): ≤ 137 °C
Assay (HPLC, area%): ≥ 95.0 % (a/a)

Informations légales

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Pictogrammes: GHS05,GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H290 - H315 - H319 - H335
• Conseils de prudence: P234 - P261 - P264 - P271 - P302 + P352 - P305 + P351 + P338
• Classification des risques: Eye Irrit. 2 - Met. Corr. 1 - Skin Irrit. 2 - STOT SE 3
• Organes cibles: Respiratory system
• Code de la classe de stockage: 8A - Combustible, corrosive hazardous materials
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable