8.22278

Acetic anhydride

for synthesis

• Synonyme(s) : Acetic anhydride, Acetyl acetate, Acetyl oxide
• Formule linéaire : (CH₃CO)₂O
• Numéro CAS: 108-24-7
• Poids moléculaire : 102.09
• Numéro MDL: MFCD00008705
• Code UNSPSC : 12352106
• Numéro de classement CE : 203-564-8
• Nomenclature NACRES : NA.22

Propriétés

• Pression de vapeur: 4 hPa ( 20 °C)
• Niveau de qualité: 200
• Pureté: ≥98.0% (GC)
• Forme: liquid
• Température d'inflammation spontanée: 330 °C
• Puissance: 630 mg/kg LD₅₀, oral (Rat); 4320 mg/kg LD₅₀, skin (Rabbit)
• Limite d'explosivité: 2.0-10.2 % (v/v)
• pH: 3 (20 °C, 10 g/L in H₂O)
• Pf: -73 °C
• Température de transition: flash point 49 °C
• Densité: 1.08 g/cm³ at 20 °C
• Température de stockage: 2-30°C
• InChI: 1S/C4H6O3/c1-3(5)7-4(2)6/h1-2H3
• Clé InChI: WFDIJRYMOXRFFG-UHFFFAOYSA-N

Description

Description générale

Acetic anhydride is a widely used reagent in organic synthesis. The reagent is effective for acetylating alcohols, amines, and thiols. Additionally, it is used in various named reactions such as the Pummerer reaction, the Perkin reaction, the Polonovski reaction, the N-oxide reaction, and the Thiele reaction. Acetic anhydride is an effective reagent during oxidation of alcohols, dehydration, ether cleavage, enol acetate formation, and gem-diacetate formation.

Application

Acetic anhydride is used:

• In the solvent free acylation of 2-methylfuran to 2-acetyl-5-methylfuran in presence of hydroxide fluorides catalyst.
• As a catalyst in the synthesis of 3-arylideneisobenzofuran-1(3H)-one derivatives from phthalic anhydride and quinoline derivatives.
• In the preparation of hyperbranched poly ethoxy siloxanes by condensation reaction with tetra ethoxy silane in presence of an organotitanium catalyst.

Remarque sur l'analyse

Assay (GC, area%): ≥ 98.0 % (a/a)
Density (d 20 °C/ 4 °C): 1.080 - 1.082
Identity (IR): passes test

Informations sur la sécurité

• Pictogrammes: GHS02,GHS05,GHS06
• Mention d'avertissement: Danger
• Mentions de danger: H226 - H302 - H314 - H330
• Conseils de prudence: P210 - P280 - P301 + P312 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• Classification des risques: Acute Tox. 2 Inhalation - Acute Tox. 4 Oral - Eye Dam. 1 - Flam. Liq. 3 - Skin Corr. 1B
• Code de la classe de stockage: 3 - Flammable liquids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): 120.2 °F - closed cup
• Point d'éclair (°C): 49 °C - closed cup