566330-M

SIRT1/2 Inhibitor VIII, Salermide

The SIRT1/2 Inhibitor VIII, Salermide, also referenced under CAS 1105698-15-4, controls the biological activity of SIRT1/2. This small molecule/inhibitor is primarily used for Cell Structure applications.

• Synonyme(s) : SIRT1/2 Inhibitor VIII, Salermide, N-(3-((2-Hydroxynaphthalen-1-ylmethylene)-amino)-phenyl)-2-phenyl-propionamide, SIRT1 Inhibitor VI, SIRT2 Inhibitor VIII
• Formule empirique (notation de Hill): C₂₆H₂₂N₂O₂
• Numéro CAS: 1105698-15-4
• Poids moléculaire : 394.47
• Numéro MDL: MFCD12912446
• Code UNSPSC : 12352200

Propriétés

• Niveau de qualité: 100
• Pureté: ≥95% (HPLC)
• Forme: solid
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; protect from light
• Couleur: yellow
• Solubilité: DMSO: 5 mg/mL
• Température de stockage: 2-8°C
• InChI: 1S/C26H22N2O2/c1-18(19-8-3-2-4-9-19)26(30)28-22-12-7-11-21(16-22)27-17-24-23-13-6-5-10-20(23)14-15-25(24)29/h2-18,29H,1H3,(H,28,30)
• Clé InChI: HQSSEGBEYORUBY-UHFFFAOYSA-N

Description

Description générale

A cell-permeable 2-hydroxy-naphthaldehyde that acts as an inhibitor against sirtuins SirT1 and SirT2, members of class III HDACs. Salermide effectively inhibits the activity of both SirT1 and SirT2 (by 80% at 100 and 25 µM, respectively), while its structural analogue Sirtinol (Cat. Nos. 566320 and 566321), at 100 µM concentration, inhibits SirT2 only by up to 60% and is of no effect against SirT1. Salermide is also shown to be at least 2-fold more potent than Sirtinol (both at 100 µM) in killing leukemia KG1A and lymphoma Raji cultures.

A cell-permeable 2-hydroxy-naphthaldehyde that acts as an inhibitor against sirtuins SirT1 and SirT2, members of class III HDACs. Salermide effectively inhibits the activity of both SirT1 and SirT2 (by 80% at 100 and 25 µM, respectively), while its structural analogue Sirtinol (Cat. Nos. 566320 & 566321), at 100 µM concentration, inhibits SirT2 only by up to 60% and is of no effect against SirT1. Salermide is also shown to be at least 2-fold more potent than Sirtinol (both at 100 µM) in killing leukemia KG1A and lymphoma Raji cultures.

Avertissement

Toxicity: Standard Handling (A)

Autres remarques

Lara, E., et al. 2009. Oncogene28, 781.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3