540500

Purvalanol A

A potent, cell-permeable, reversible, and selective inhibitor of cyclin-dependent kinases.

• Synonyme(s) : Purvalanol A, 2-(1R-Isopropyl-2-hydroxyethylamino)-6-(3-chloroanilino)-9-isopropyl-purine
• Formule empirique (notation de Hill): C₁₉H₂₅ClN₆O
• Numéro CAS: 212844-53-6
• Poids moléculaire : 388.89
• Numéro MDL: MFCD02179211
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Essai: ≥97% (HPLC)
• Forme: solid
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze
• Couleur: off-white
• Solubilité: DMSO: 100 mg/mL
• Conditions d'expédition: ambient
• Température de stockage: −20°C
• Chaîne SMILES: Clc1cc(ccc1)Nc2nc(nc3[n](cnc32)C(C)C)N[C@@H](CO)C(C)C
• InChI: 1S/C19H25ClN6O/c1-11(2)15(9-27)23-19-24-17(22-14-7-5-6-13(20)8-14)16-18(25-19)26(10-21-16)12(3)4/h5-8,10-12,15,27H,9H2,1-4H3,(H2,22,23,24,25)/t15-/m0/s1
• Clé InChI: PMXCMJLOPOFPBT-HNNXBMFYSA-N

Description

Description générale

A potent, cell-permeable, reversible, and selective inhibitor of cyclin-dependent kinases (Cdks; IC₅₀ = 4 nM for Cdc2-cyclin B; IC₅₀ = 70 nM for Cdk2-cyclin A; IC₅₀ = 35 nM for Cdk2-cyclin E; and IC₅₀ = 75 nM for Cdk5-p35).

A potent, cell-permeable, reversible, and selective inhibitor of cyclin-dependent kinases (Cdks; IC₅₀ = 4 nM for Cdc2/cyclin B; IC₅₀ = 70 nM for Cdk2/cyclin A; IC₅₀ = 35 nM for Cdk2/cyclin E; and IC₅₀ = 75 nM for Cdk5/p35).

Actions biochimiques/physiologiques

Cell permeable: yes

Primary Target
Cdc2/cyclin B

Product does not compete with ATP.

Reversible: yes

Target IC₅₀: 4 nM for Cdc2/cyclin B; 70 nM for Cdk2/cyclin A; 35 nM for Cdk2/cyclin E; 75 nM for Cdk5/p35

Conditionnement

Packaged under inert gas

Avertissement

Toxicity: Standard Handling (A)

Reconstitution

Following initial thaw, aliquot and freeze (-20°C).

Autres remarques

Gray, N.S., et al. 1998. Science 281, 533.

Informations légales

Sold under license of U.S. Patents 6,617,331 and 6,803,371.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3