468495

1,1′-Dioctadecyl-3,3,3′,3′-tetramethylindocarbocyanine perchlorate

97%

• Synonyme(s) : DiI
• Formule empirique (notation de Hill): C₅₉H₉₇ClN₂O₄
• Numéro CAS: 41085-99-8
• Poids moléculaire : 933.87
• Numéro Beilstein : 8251870
• Numéro MDL: MFCD00142354
• Code UNSPSC : 12171500
• ID de substance PubChem : 24870519
• Nomenclature NACRES : NA.47

Propriétés

• Pureté: 97%
• Forme: crystalline
• Composition: Carbon: 73.2-78.5%; ; Nitrogen: 2.7-3.3%
• Technique(s): titration: suitable
• Couleur: dark purple
• Pf: 68 °C (dec.) (lit.)
• λmax: 549 nm
• ε (coefficient d'extinction): ≥10000 at 276-282 nm in methanol at 0.01 g/L; ≥130000 at 546-552 nm in methanol at 0.01 g/L; ≥70000 at 514-520 nm in methanol at 0.01 g/L
• Application(s): diagnostic assay manufacturing; hematology; histology
• Température de stockage: 2-8°C
• Chaîne SMILES: [O-]Cl(=O)(=O)=O.CCCCCCCCCCCCCCCCCCN1c2ccccc2C(C)(C)/C1=C\C=C\C3=[N+](CCCCCCCCCCCCCCCCCC)c4ccccc4C3(C)C
• InChI: 1S/C59H97N2.ClHO4/c1-7-9-11-13-15-17-19-21-23-25-27-29-31-33-35-41-50-60-54-46-39-37-44-52(54)58(3,4)56(60)48-43-49-57-59(5,6)53-45-38-40-47-55(53)61(57)51-42-36-34-32-30-28-26-24-22-20-18-16-14-12-10-8-2;2-1(3,4)5/h37-40,43-49H,7-36,41-42,50-51H2,1-6H3;(H,2,3,4,5)/q+1;/p-1
• Clé InChI: JVXZRNYCRFIEGV-UHFFFAOYSA-M

Description

Description générale

1,1′-Dioctadecyl-3,3,3′,3′-tetramethylindocarbocyanine perchlorate is also called as Dil. It can be used to study HCV (Hepatitis C virus) cell interactions in the HCV entry process. It is used to label oxidized LDL (low-density lipoprotein) to quantify the uptake of DiI-oxLDL in human endothelial cells.

Application

1,1′-Dioctadecyl-3,3,3′,3′-tetramethylindocarbocyanine perchlorate has been used in cytoskeletal staining, nuclear staining, retrograde labeling, counting of motor neurons and labelling of the retinal ganglion cell axons.

1,1′-Dioctadecyl-3,3,3′,3′-tetramethylindocarbocyanine perchlorate has been used in fluorescent labelling of mesenchymal stem cells (MSCs) and cerebral cortex. It has also been used in electromyogram (EMG) to determine awake and anesthetized states in mice.

Actions biochimiques/physiologiques

Lipophilic carbocyanine dye used primarily for optical recordings of membrane voltage and for studies of membrane fluidity. Retrograde stain for neurons; provides intense, long-lasting staining of live neurons in vivo and in vitro.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)