475870
MnTBAP
≥95% (TLC), solid, SOD mimetic, Calbiochem®
Synonyme(s) :
MnTBAP, Mn(III)tetrakis(4-benzoic acid)porphyrin Chloride
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About This Item
Formule empirique (notation de Hill):
C48H28ClMnN4O8
Numéro CAS:
Poids moléculaire :
879.15
Code UNSPSC :
12352200
Nomenclature NACRES :
NA.77
Produits recommandés
product name
MnTBAP, Cell-permeable superoxide dismutase (SOD) mimetic and peroxynitrite scavenger.
Niveau de qualité
Pureté
≥95% (TLC)
Forme
solid
Fabricant/nom de marque
Calbiochem®
Conditions de stockage
OK to freeze
desiccated
protect from light
Couleur
brown
Solubilité
aqueous base: soluble
Conditions d'expédition
ambient
Température de stockage
−20°C
Description générale
Cell-permeable superoxide dismutase (SOD) mimetic and peroxynitrite scavenger. Protects endothelial cells in a dose-dependent manner (EC50 ~40 µM) against paraquat (2 mM). Inhibits the oxidation of Dihydrorhodamine 123 (Cat. No. 309825) by peroxynitrite, but does not scavenge nitric oxide (NO).
Cell-permeable superoxide dismutase (SOD) mimetic and peroxynitrite scavenger. Protects endothelial cells in a dose-dependent manner (EC50 ~40 µM) against paraquat (2 mM). Inhibits the oxidation of dihydrorhodamine-123 by peroxynitrite, but does not scavenge nitric oxide (NO).
Actions biochimiques/physiologiques
Cell permeable: yes
EC50 ~40 µM in protecting endothelial cells against paraquat (2 mM)
Primary Target
Superoxide dismutase (SOD) mimetic
Superoxide dismutase (SOD) mimetic
Product does not compete with ATP.
Reversible: no
Avertissement
Toxicity: Standard Handling (A)
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Autres remarques
Aladag, M. A., et al. 2003. Acta Neurochir.145, 673.
Szabo, C., et al. 1996. FEBS Lett. 381, 82.
Day, B.J., et al. 1995. J. Pharmacol. Exp. Ther. 275, 1227.
Faulkner, K.M., et al. 1994. J. Biol. Chem. 269, 23471.
Szabo, C., et al. 1996. FEBS Lett. 381, 82.
Day, B.J., et al. 1995. J. Pharmacol. Exp. Ther. 275, 1227.
Faulkner, K.M., et al. 1994. J. Biol. Chem. 269, 23471.
Informations légales
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Code de la classe de stockage
11 - Combustible Solids
Classe de danger pour l'eau (WGK)
WGK 1
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Certificats d'analyse (COA)
Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".
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Les clients ont également consulté
B J Day et al.
The Journal of pharmacology and experimental therapeutics, 275(3), 1227-1232 (1995-12-01)
There is an increased interest in development of therapeutic agents to treat disease states that involve reactive oxygen species in their pathophysiology. The metalloporphyrins, MnTBAP and ZnTBAP, were found to be active in a superoxide dismutase (SOD) assay. The efficacy
K M Faulkner et al.
The Journal of biological chemistry, 269(38), 23471-23476 (1994-09-23)
Several manganic porphyrins, with substituents on the methine bridge carbons, were prepared and examined for stability, redox behavior, catalysis of the dismutation of superoxide radical (O2-), and the ability to protect a superoxide dismutase (SOD)-null strain of E. coli against
C Szabó et al.
FEBS letters, 381(1-2), 82-86 (1996-02-26)
Here we report that the cell-permeable superoxide dismutase mimetic Mn(III)tetrakis (4-benzoic acid) porphyrin (MnTBAP) inhibits the oxidation of dihydrorhodamine-123 by peroxynitrite, but does not scavenge nitric oxide (NO). MnTBAP protects against the suppression of mitochondrial respiration in J774 cells exposed
M A Aladag et al.
Acta neurochirurgica, 145(8), 673-677 (2003-10-02)
Delayed cerebral vasoconstriction and brain ischemia, are critical problems in the management of a patient affected by rupture of an intracranial aneurysm. Overexpression of Cu-Zn superoxide dismutase (Cu-Zn SOD) can reduce the extent of cerebral vasospasm. We, therefore investigated if
Maria Catalina Gomez-Puerto et al.
International journal of molecular sciences, 21(11) (2020-06-14)
Pulmonary arterial hypertension (PAH) is a life-threatening disease characterized by obstructed pulmonary vasculatures. Current therapies for PAH are limited and only alleviate symptoms. Reduced levels of BMPR2 are associated with PAH pathophysiology. Moreover, reactive oxygen species, inflammation and autophagy have
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