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400046

Sigma-Aldrich

Hydroxyurea

≥98% (HPLC), solid, RNR inhibitor, Calbiochem

Synonyme(s) :

Hydroxyurea, Ribonucleotide Reductase Inhibitor I, RNR Inhibitor I

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About This Item

Formule empirique (notation de Hill):
CH4N2O2
Numéro CAS:
127-07-1
Poids moléculaire :
76.05
Numéro MDL:
MFCD00007943
Code UNSPSC :
12352200
Nomenclature NACRES :
NA.77

product name

Hydroxyurea, Anti-neoplastic agent that blocks DNA replication by inhibiting ribonucleotide reductase.

Niveau de qualité

100

Pureté

≥98% (HPLC)

Forme

solid

Fabricant/nom de marque

Calbiochem®

Conditions de stockage

OK to freeze

Couleur

white

Solubilité

water: 5 mg/mL

Conditions d'expédition

ambient

Température de stockage

2-8°C

InChI

1S/CH4N2O2/c2-1(4)3-5/h5H,(H3,2,3,4)

Clé InChI

VSNHCAURESNICA-UHFFFAOYSA-N

Description générale

Anti-neoplastic agent that blocks DNA replication by inhibiting ribonucleotide reductase. Induces apoptosis in chronic myelogenous leukemia lymphocytes. Reported to enhance the radiation effects in pancreatic adenocarcinoma cells. Releases NO in the presence of oxidizing agents.
Antineoplastic agent. Blocks DNA replication by inhibiting ribonucleotide reductase. Induces apoptosis in chronic myelogenous leukemia lymphocytes.

Actions biochimiques/physiologiques

Cell permeable: no
Primary Target
Inhibiting ribonucleotide reductase
Product does not compete with ATP.
Reversible: no

Avertissement

Toxicity: Carcinogenic / Teratogenic (D)

Reconstitution

Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 2 months at 4°C.

Autres remarques

Leyden, D., et al. 2000. Anticancer Res.20, 133.
Tsuchiya, K., et al. 1999. Free Radic. Biol. Med. 27, 347.
Anand, S., et al. 1995. Cancer Lett.88, 101.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Pictogrammes

Health hazard
GHS08

Mention d'avertissement

Danger

Mentions de danger

H340,H361

Classification des risques

Muta. 1B - Repr. 2

Code de la classe de stockage

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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