341610

FGF/PDGF/VEGF RTK Inhibitor

The FGF/PDGF/VEGF RTK Inhibitor, also referenced under CAS 144335-37-5, controls the biological activity of FGF/PDGF/VEGF RTK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• Synonyme(s) : FGF/PDGF/VEGF RTK Inhibitor, 4-Hydroxy-3-benzimidazol-2-ylhydroquinolin-2-one, PDGFR Tyrosine Kinase Inhibitor XVII, VEGFR Tyrosine Kinase Inhibitor XXX, VEGFR2 Kinase Inhibitor XXVIII, PDGFR Tyrosine Kinase Inhibitor XVII, 4-Hydroxy-3-benzimidazol-2-ylhydroquinolin-2-one, VEGFR Tyrosine Kinase Inhibitor XXX, VEGFR2 Kinase Inhibitor XXVIII
• Formule empirique (notation de Hill): C₁₆H₁₁N₃O₂
• Numéro CAS: 144335-37-5
• Poids moléculaire : 277.28
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Pureté: ≥95% (HPLC)
• Forme: solid
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; protect from light
• Couleur: off-white
• Solubilité: DMSO: 5 mg/mL
• Conditions d'expédition: ambient
• Température de stockage: 2-8°C
• InChI: 1S/C16H11N3O2/c20-14-9-5-1-2-6-10(9)19-16(21)13(14)15-17-11-7-3-4-8-12(11)18-15/h1-8H,(H,17,18)(H2,19,20,21)
• Clé InChI: YXCWBNCDJZEBKY-UHFFFAOYSA-N

Description

Description générale

A cell-permeable benzimidazolo-hydroquinolinone compound that acts as a potent, reversible, ATP-competitive inhibitor against PDGFRβ, FGFR-1, and VEGFR-2 (IC₅₀ = 20, 90, and 240 nM, respectively) and effectively suppresses VEGF-stimulated proliferation of HMVECs (EC₅₀ = 420 nM).

Conditionnement

Packaged under inert gas

Avertissement

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Autres remarques

Renhowe, P.A., et al. 2009. J. Med. Chem.52, 278.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 2
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable