203694

bpV(bipy)

A potent inhibitor of phosphotyrosine phosphatase (K_i = 100 nM for insulin receptor dephosphorylation).

• Synonyme(s) : bpV(bipy), Potassium Bisperoxo(bipyridine)oxovanadate (V), PTEN Inhibitor II, PTP Inhibitors XIV
• Formule linéaire : K[VO(O₂)₂C₁₀H₈N₂] · 3H₂O
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Pureté: ≥95% (⁵¹V-NMR)
• Forme: solid
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; protect from light
• Couleur: yellow to orange
• Solubilité: water: 5 mg/mL
• Conditions d'expédition: ambient
• Température de stockage: −20°C

Description

Description générale

A potent inhibitor of phosphotyrosine phosphatase (K_i = 100 nM for insulin receptor dephosphorylation). An activator of insulin receptor kinase (IRK). Also reported to be a potent inhibitor of PTEN (IC₅₀ = 18 nM).

A potent inhibitor of phosphotyrosine phosphatase activity (K_i = 100 nM for insulin receptor dephosphorylation). An activator of insulin receptor kinase (IRK). Also reported to be a potent inhibitor of PTEN (IC₅₀ = 18 nM).

Actions biochimiques/physiologiques

Cell permeable: no

Primary Target
phosphotyrosine phosphatase

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 18 nM against PTEN

Target K_i: 100 nM for phosphotyrosine phosphatase

Conditionnement

Packaged under inert gas

Avertissement

Toxicity: Harmful (C)

Reconstitution

Unstable in solution; reconstitute just prior to use.

Autres remarques

Schmid, A.C., et al. 2004. FEBS Lett.566, 35.
Posner, B.I., et al. 1994. J. Biol. Chem. 269, 4596.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable