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Merck
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Key Documents

19-144

Sigma-Aldrich

Phorbol 12-Myristate 13-Acetate

≥99% (HPLC), solid, PKC activator, Upstate®

Synonyme(s) :

12-O-Tetradecanoylphorbol 13-acetate, 4β,9α,12β,13α,20-Pentahydroxytiglia-1,6-dien-3-one 12-tetradecanoate 13-acetate, PMA, TPA

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About This Item

Code UNSPSC :
12352211
eCl@ss :
32160405
Nomenclature NACRES :
NA.41

product name

Phorbol 12-Myristate 13-Acetate,

Forme

solid

Niveau de qualité

100

Fabricant/nom de marque

Upstate®

Technique(s)

activity assay: suitable (kinase)

Conditions d'expédition

wet ice

Description générale

Phorbol 12-Myristate 13-Acetate (PMA) is obtained from the unripe fruit of Sapium indicum. It is a pro-inflammatory agent. PMA shows its effects by the release of cytokines, nicotinamide adenine dinucleotide phosphate (NADPH) oxidases, and proteases that result in tissue damage or activates histamine production. This promotes vascular remodeling, heat, and redness. PMA exhibits antimicrobial, proliferative, antiproliferative, anti-neoplastic effects.

Application

Phorbol 12-Myristate 13-Acetate is suitable as an inducer of cell differentiation in monocytic cell lines such as U937 and THP-1.

Actions biochimiques/physiologiques

Phorbol 12-Myristate 13-Acetate is a tumor-promoting phorbol ester. It regulates various processes such as gene transcription, cellular growth and differentiation, apoptosis, the immune response, and receptor desensitization via activating protein kinase C (PKC) signaling pathways. It promotes differentiation of human monocytic THP-1 cells to functional macrophages.

Forme physique

C36H56O8

Stockage et stabilité

2 years at -20°C

Informations légales

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Pictogrammes

Skull and crossbonesHealth hazardCorrosion
GHS06,GHS08,GHS05

Mention d'avertissement

Danger

Classification des risques

Acute Tox. 1 Dermal - Acute Tox. 1 Inhalation - Acute Tox. 2 Oral - Carc. 2 - Eye Dam. 1 - Resp. Sens. 1 - Skin Corr. 1B - Skin Sens. 1

Code de la classe de stockage

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

Classe de danger pour l'eau (WGK)

WGK 3

Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

Agnes Schröder et al.
Journal of orofacial orthopedics = Fortschritte der Kieferorthopadie : Organ/official journal Deutsche Gesellschaft fur Kieferorthopadie (2022-04-22)
Orthodontic tooth movement is a complex process involving the remodeling of extracellular matrix and bone as well as inflammatory processes. During orthodontic treatment, sterile inflammation and mechanical loading favor the production of receptor activator of NF-κB ligand (RANKL). Simultaneously, expression of
In vitro studies on the mode of action of the phorbol esters, potent tumor promoters: part 1.
Blumberg, P M
Critical Reviews in Toxicology, 8, 153-197 (1980)
Phorbol 12-myristate 13-acetate upregulates cyclooxygenase-2 expression in human pulmonary epithelial cells via Ras, Raf-1, ERK, and NF-kappaB, but not p38 MAPK, pathways.
Chang, et al.
Cellular Signalling, 17, 299-310 (2018)
Phorbol 12-Myristate 13-Acetate Induced Toxicity Study and the Role of Tangeretin in Abrogating HIF-1?-NF-?B Crosstalk In Vitro and In Vivo
Sukkum N C, et al.
International Journal of Molecular Sciences, 21(23), 9261-9261 (2020)
Kassim Traore et al.
Leukemia research, 29(8), 863-879 (2005-06-28)
Human monocytic THP-1 cells can be induced to differentiate to macrophages when treated with phorbol 12-myristate 13-acetate (PMA). It is understood that before initiating cell differentiation, PMA treatment must first induce an inhibition of cell growth. Since the initial biochemical
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