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Merck
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Key Documents

12668-M

Sigma-Aldrich

Albumin, Human Serum, Fraction V

Synonyme(s) :

Albumin, Human Serum, Fraction V

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About This Item

Numéro CAS:
70024-90-7
Numéro MDL:
MFCD00081418
Code UNSPSC :
12352202

Pureté

≥95% (SDS-PAGE)

Forme

solid

Fabricant/nom de marque

Calbiochem®

Conditions de stockage

OK to freeze

Solubilité

water: 20 mg/mL

Température de stockage

2-8°C

InChI

1S/C3F8/c4-1(5,2(6,7)8)3(9,10)11

Clé InChI

QYSGYZVSCZSLHT-UHFFFAOYSA-N

Description générale

Human serum albumin (HSA), a globular, soluble, and unglycosylated monomeric protein, is the most abundant protein in the plasma. It is a multidomain protein consisting of three homologous domains, named I, II, and III. Each of these domains contains subdomains A and B possessing common structural motifs. The HSA gene is present on the human chromosome location 4q13.3.

Actions biochimiques/physiologiques

Human serum albumin (HSA) serves as a carrier protein for fatty acids, thyroid hormones, and steroids. It plays a critical role in stabilizing extracellular fluid volume. HSA acts as an excipient for vaccines and therapeutic protein drugs. It is also used as a cell culture medium supplement to produce vaccines and pharmaceuticals. HSA is used to treat hemodialysis, acute liver failure, chronic liver disease. HSA has importance in biological applications, such as ligand trapping, nano delivery of drugs, and fusion proteins.

Avertissement

Toxicity: Standard Handling (A)

Reconstitution

Following recosntitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

Yang He et al.
Proceedings of the National Academy of Sciences of the United States of America, 108(47), 19078-19083 (2011-11-02)
Human serum albumin (HSA) is widely used in clinical and cell culture applications. Conventional production of HSA from human blood is limited by the availability of blood donation and the high risk of viral transmission from donors. Here, we report
Gabriella Fanali et al.
Molecular aspects of medicine, 33(3), 209-290 (2012-01-11)
Human serum albumin (HSA), the most abundant protein in plasma, is a monomeric multi-domain macromolecule, representing the main determinant of plasma oncotic pressure and the main modulator of fluid distribution between body compartments. HSA displays an extraordinary ligand binding capacity
Angelica M Merlot et al.
Frontiers in physiology, 5, 299-299 (2014-08-28)
Serum albumin is a multi-functional protein that is able to bind and transport numerous endogenous and exogenous compounds. The development of albumin drug carriers is gaining increasing importance in the targeted delivery of cancer therapy, particularly as a result of

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