112252

Acidic Mammalian Chitinase Inhibitor, Bisdionin F

The Acidic Mammalian Chitinase Inhibitor, Bisdionin F controls the biological activity of Acidic Mammalian Chitinase.

• Synonyme(s) : Acidic Mammalian Chitinase Inhibitor, Bisdionin F, AMCase Inhibitor, 3,7-dimethyl-1-(3-(3-methyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-1-yl)propyl)-1H-purine-2,6(3H,7H)-dione
• Formule empirique (notation de Hill): C₁₆H₁₈N₈O₄
• Numéro CAS: 917877-86-2
• Poids moléculaire : 386.37
• Code UNSPSC : 12352106
• Nomenclature NACRES : NA.54

Propriétés

• Niveau de qualité: 100
• Pureté: ≥95% (HPLC)
• Forme: powder
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; protect from light
• Couleur: off-white
• Solubilité: DMSO: 5 mg/mL, clear, nearly colorless
• Conditions d'expédition: ambient
• Température de stockage: 2-8°C
• Chaîne SMILES: CN(C=N1)C2=C1N(C)C(N(C2=O)CCCN3C(N(C)C(N=CN4)=C4C3=O)=O)=O

Description

Description générale

A cell-permeable, competitive Acidic Mammalian Chitinase (AMCase) Inhibitor (IC₅₀ = 0.92 µM and K_i = 0.42 µM for hAMCase, and IC₅₀= 2.2 µM for mAMCase, in vitro) that demonstrates 20-fold selectivity for hAMCase over hCHIT1. It is shown to decrease chitinase enzymatic activity (5 mg/kg, i.p.) in the lungs of control PBS- and OVA-challenged mice. Furthermore, it attenuates lung chitinase activity, reduces eosinophil influx, and improves ventilatory function, in vivo, in a murine model of allergic inflammation. It also causes neutrophilia in the lungs of OVA-challenged mice.

Conditionnement

Packaged under inert gas

Avertissement

Toxicity: Standard Handling (A)

Autres remarques

Sutherland, T.E., et al. 2011. Chem. Biol.18, 569.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable