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Merck
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Key Documents

07-122

Sigma-Aldrich

Anti-Kalirin Antibody

Upstate®, from rabbit

Synonyme(s) :

Anti-ARHGEF24, Anti-CHDS5, Anti-DUET, Anti-DUO, Anti-HAPIP, Anti-TRAD

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About This Item

Code UNSPSC :
12352203
eCl@ss :
32160702
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Niveau de qualité

100

Forme d'anticorps

purified antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Espèces réactives

rat, mouse

Fabricant/nom de marque

Upstate®

Technique(s)

immunocytochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable

Isotype

IgG

Numéro d'accès NCBI

NM_032062

Numéro d'accès UniProt

O60229

Conditions d'expédition

wet ice

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... KALRN(8997)

Spécificité

Kalirin; does not cross react with Trio

Immunogène

GST fusion protein corresponding to residues 517-976 of rat Kalirin, cleaved with thrombin to remove the GST moiety; referred to as JH2582

Application

Anti-Kalirin Antibody is an antibody against Kalirin for use in IP, WB & IC.
Research Category
Signaling
Research Sub Category
G-proteins

Cytoskeletal Signaling

Qualité

routinely evaluated by immunoblot on RIPA lysates from rat brain microsomal protein preparation; long exposure times may be required

Description de la cible

190, 115, 370 and 420kDa isoforms

Forme physique

0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide prior to the addition of glycerol to 30%
Format: Purified
Protein A chromatography

Stockage et stabilité

2 years at -20°C

Informations légales

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 1

Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

R E Mains et al.
The Journal of biological chemistry, 274(5), 2929-2937 (1999-01-23)
The production and regulated secretion of bioactive peptides require a series of lumenal enzymes to convert inactive precursors into bioactive peptides plus several cytosolic proteins to govern granule formation, maturation, translocation, and exocytosis. Peptidylglycine alpha-amidating monooxygenase (PAM), an enzyme essential
Kalirin inhibition of inducible nitric-oxide synthase.
Ratovitski, E A, et al.
The Journal of Biological Chemistry, 274, 993-999 (1999)
P Penzes et al.
The Journal of biological chemistry, 275(9), 6395-6403 (2000-02-29)
Communication between membranes and the actin cytoskeleton is an important aspect of neuronal function. Regulators of actin cytoskeletal dynamics include the Rho-like small GTP-binding proteins and their exchange factors. Kalirin is a brain-specific protein, first identified through its interaction with
The Rho-GEF Kalirin regulates bone mass and the function of osteoblasts and osteoclasts.
Huang, S; Eleniste, PP; Wayakanon, K; Mandela, P; Eipper, BA; Mains, RE; Allen, MR; Bruzzaniti, A
Bone null
Deepak P Srivastava et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 32(34), 11864-11878 (2012-08-24)
Deficits in social and communication behaviors are common features of a number of neurodevelopmental disorders. However, the molecular and cellular substrates of these higher order brain functions are not well understood. Here we report that specific alterations in social and
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