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Key Documents

05-382

Sigma-Aldrich

Anti-Na+/K+ ATPase β-1 Antibody, clone C464.8

clone C464.8, Upstate®, from mouse

Synonyme(s) :

Anti-AHC2, Anti-ATP1A1, Anti-CAPOS, Anti-DEE99, Anti-DYT12, Anti-RDP

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About This Item

Code UNSPSC :
12352203
eCl@ss :
32160702
Nomenclature NACRES :
NA.41

Source biologique

mouse

Niveau de qualité

100

Forme d'anticorps

purified immunoglobulin

Type de produit anticorps

primary antibodies

Clone

C464.8, monoclonal

Espèces réactives

rabbit, bovine, canine, human, rat

Fabricant/nom de marque

Upstate®

Technique(s)

immunohistochemistry: suitable
western blot: suitable

Isotype

IgG2aκ

Numéro d'accès NCBI

NM_001677

Numéro d'accès UniProt

P13637

Conditions d'expédition

dry ice

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... ATP1A3(478)

Description générale

Clone C464.8 is also referred to as clone 8A

Spécificité

Recognizes the β-1 subunit isoform of Na+/K+.

Immunogène

Purified Na+/K+ ATPase isolated from membrane fractions of rabbit kidney outer medulla.

Application

Research Category
Neuroscience
Research Sub Category
Ion Channels & Transporters
This Anti-Na+/K+ ATPase β-1 Antibody, clone C464.8 is validated for use in IH, WB for the detection of Na+/K+ ATPase β-1.

Qualité

routinely evaluated in immunoblot on rat brain, rat heart or rat kidney microsomal preparations

Description de la cible

broad band at an apparent molecular weight of 48-55 kDa due to glycosylation

Forme physique

Format: Purified
Protein G Purified
Protein G Purified immunoglobulin in Protein G Purified immunoglobulin in PBS with 0.05% sodium azide before the addition of glycerol to 30%

Stockage et stabilité

Maintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Remarque sur l'analyse

Control
Expressed in most tissue, including brain, heart and kidney

Autres remarques

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Informations légales

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

12 - Non Combustible Liquids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Aude Belliard et al.
Physiological reports, 4(19) (2016-10-06)
Cardiac glycosides (CG) are traditionally known as positive cardiac inotropes that inhibit Na+/K+-ATPase-dependent ion transport. CG also trigger-specific signaling pathways through the cardiac Na+/K+-ATPase, with beneficial effects in ischemia/reperfusion (I/R) injury (e.g., ouabain preconditioning, known as OPC) and hypertrophy. Our
Analysis of subunit assembly of the Na-K-ATPase.
Fambrough, D M, et al.
The American Journal of Physiology, 266, C579-C589 (1994)
Regional distribution of Na,K-ATPase activity in porcine lens epithelium
Tamiya, S., et al
Investigative Ophthalmology & Visual Science, 44, 4395-4399 (2003)
Man Liang et al.
The Journal of biological chemistry, 282(14), 10585-10593 (2007-02-14)
Recent studies have ascribed many non-pumping functions to the Na/K-ATPase. Here, we present experimental evidence demonstrating that over half of the plasma membrane Na/K-ATPase in LLC-PK1 cells is performing cellular functions other than ion pumping. This "non-pumping" pool of Na/K-ATPase
Motor neuron degeneration in amyotrophic lateral sclerosis mutant superoxide dismutase-1 transgenic mice: mechanisms of mitochondriopathy and cell death.
Lee J Martin,Zhiping Liu,Kevin Chen,Ann C Price,Yan Pan,Jason A Swaby,W Christopher Golden
The Journal of Comparative Neurology null
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