03-0211-00

SMC^® Human pTau231 High Sensitivity Immunoassay Kit

• Synonyme(s) : SMC^® Human pTau231 High Sensitivity Immunoassay Kit, pTau231 Single Molecule Counting kit, pTau231 immunoassay kit, pTau231 ultra-sensitive immunoassay, phospho Tau 231 immunoassay kit
• Code UNSPSC : 12161503
• Nomenclature NACRES : NA.55

Propriétés

• Description: 100uL (neat Serum, 1:2 diluted Plasma or 1:4 diluted CSF samples); kit sufficient for 96 wells
• Niveau de qualité: 200
• Espèces réactives: human
• Fabricant/nom de marque: SMC^®
• assay range: intra-assay cv: ≤10%; (n=15); recovery range: 44-68%; (K2EDTA Plasma); recovery range: 68-100%; (Serum); recovery range: 90-130%; (CSF); sensitivity: 1.95 pg/mL; (lower limit of quantification); standard curve range: 0.49-500 pg/mL; inter-assay cv: ≤20%; (n=15)
• Technique(s): single molecule counting: suitable
• Entrée: serum; cerebrospinal fluid (CSF); plasma (K2EDTA)
• Conditions d'expédition: wet ice
• Température de stockage: 2-8°C

Description

Description générale

Tau protein is primarily a structural protein in neurons of the central nervous. Found as at least six different isoforms, these proteins are thought to provide structure, enable signaling, and regulate transport. In disease states, Tau proteins can become hyperphosphorylated and create tauopathies in the form of neurofibrillary or gliofibrillary tangles commonly associated with Alzheimer’s or Parkinson’s disease. Tau protein phosphorylated at threonine-231 is referred to as Phospho-Tau231 (pTau231). pTau231 is thought to be a promising marker for Alzheimer’s disease as it can be detected in serum or plasma and is strongly associated with physiological brain changes.

Research category : Neuroscience
Research sub-category : Alzheimer′s Disease;Aging;Nervous System;Neurodegenerative Diseases;Neuroscience

Spécificité

This assay was tested for cross-reactivity with pTau181 and pTau217. No cross-reactivity was detected with either analyte.

Application

For SMC: used for ultrasensitivite quantification of Human pTau231 in human serum, plasma, and cerebrospinal fluid.

Caractéristiques et avantages

This SMC^® kit features:

• Accurate and reproducible performance on the state-of-the-art SMCxPRO^® ultrasensitive immunoassay system.
• Compatiblity with automated liquid handling

Autres remarques

SMC is a trademark of Singulex
SMCxPRO is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations légales

SMC is a registered trademark of Singulex

SMCxPRO is a registered trademark of Merck KGaA, Darmstadt, Germany

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informations sur la sécurité

• Pictogrammes: GHS08,GHS07
• Mention d'avertissement: Danger
• Mentions de danger: H302 + H312 + H332,H319,H360FD,H373,H412
• Conseils de prudence: P273 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312 - P308 + P313
• Classification des risques: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Eye Irrit. 2 - Repr. 1B - STOT RE 2 Inhalation
• Organes cibles: Respiratory Tract
• Code de la classe de stockage: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de danger pour l'eau (WGK): WGK 3