T-039

Topiramate solution

1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant^®

• Formule empirique (notation de Hill): C₁₂H₂₁NO₈S
• Numéro CAS: 97240-79-4
• Poids moléculaire : 339.36
• Numéro CE : 200-659-6
• Code UNSPSC : 41116107
• Nomenclature NACRES : NA.24

Propriétés

• Qualité: certified reference material
• Niveau de qualité: 300
• Forme: liquid
• Caractéristiques: Snap-N-Spike^®/Snap-N-Shoot^®
• Conditionnement: ampule of 1 mL
• Fabricant/nom de marque: Cerilliant^®
• Concentration: 1.0 mg/mL in methanol
• Technique(s): gas chromatography (GC): suitable; liquid chromatography (LC): suitable
• Application(s): clinical testing
• Format: single component solution
• Température de stockage: −20°C
• Chaîne SMILES: CC1(C)O[C@@H]2CO[C@@]3(COS(N)(=O)=O)OC(C)(C)O[C@H]3[C@@H]2O1
• InChI: 1S/C12H21NO8S/c1-10(2)18-7-5-16-12(6-17-22(13,14)15)9(8(7)19-10)20-11(3,4)21-12/h7-9H,5-6H2,1-4H3,(H2,13,14,15)/t7-,8-,9+,12+/m1/s1
• Clé InChI: KJADKKWYZYXHBB-XBWDGYHZSA-N
• Informations sur le gène: human ... CA2(760) , CA4(762) , GABRA1(2554) , GABRA2(2555) , GABRA3(2556) , GABRA4(2557) , GABRA5(2558) , GABRA6(2559) , GABRB1(2560) , GABRB2(2561) , GABRB3(2562) , GABRD(2563) , GABRE(2564) , GABRG1(2565) , GABRG2(2566) , GABRG3(2567) , GABRP(2568) , GABRQ(55879) , GRIA1(2890) , GRIA2(2891) , GRIA3(2892) , GRIA4(2893) , GRIK1(2897) , GRIK2(2898) , GRIK3(2899) , GRIK4(2900) , GRIK5(2901) , SCN10A(6336) , SCN11A(11280) , SCN1A(6323) , SCN2A(6326) , SCN3A(6328) , SCN4A(6329) , SCN5A(6331) , SCN7A(6332) , SCN8A(6334) , SCN9A(6335)

Description

Description générale

A certified solution standard suitable for use in LC/MS or GC/MS applications for pharmaceutical research, clinical toxicology, or forensic testing.  Topiramate, sold under trade name Topamax^®, is an antiepileptic drug used for treatment of seizures. Topiramate in combination with the stimulant phentermine constitute the active compounds in the new weight lose drug Qsymia^®.

Application

• Topiramate research solution: Research focuses on the development of intravenous formulations of topiramate for rapid intervention in seizure emergencies, highlighting its potential in emergency medicine and critical care (Epilepsy Behav, 2023; doi: 10.1016/j.yebeh.2023.109158).


• Topiramate liquid formulation: Innovations in drug delivery include the use of topiramate-chitosan nanoparticles, which offer enhanced drug stability and targeted delivery, particularly in addiction treatment settings (Neurochem Int, 2021; doi: 10.1016/j.neuint.2021.105157).


• Anticonvulsant biochemical reagent: Topiramate′s role as an anticonvulsant is further explored in studies focusing on its pharmacokinetic properties and interaction with other medications, emphasizing its importance in personalized medicine (Ther Drug Monit, 2019; doi: 10.1097/FTD.0000000000000600).


• Topiramate in vitro study: The compound is utilized in in vitro setups to investigate its effects on neuronal excitability, providing insights into its mechanism of action and potential therapeutic applications (Epilepsia, 2019; doi: 10.1111/epi.16073).


• Topiramate pharmacological research: Studies include the development of advanced analytical methods for the quantification of topiramate in biological samples, supporting its clinical monitoring and therapeutic drug management (J Pharm Biomed Anal, 2015; doi: 10.1016/j.jpba.2015.01.035).

Informations légales

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

Qsymia is a registered trademark of Vivus, Inc.

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Topamax is a registered trademark of Johnson & Johnson

Informations sur la sécurité

• Pictogrammes: GHS02,GHS06,GHS08
• Mention d'avertissement: Danger
• Mentions de danger: H225,H301 + H311 + H331,H370
• Conseils de prudence: P210 - P280 - P301 + P310 + P330 - P302 + P352 + P312 - P304 + P340 + P311
• Classification des risques: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
• Organes cibles: Eyes
• Code de la classe de stockage: 3 - Flammable liquids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): 49.5 °F - closed cup
• Point d'éclair (°C): 9.7 °C - closed cup