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M-128

Supelco

Mirtazapine solution

1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

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About This Item

Formule empirique (notation de Hill):
C17H19N3
Numéro CAS:
85650-52-8
Poids moléculaire :
265.35
Numéro CE :
200-659-6
Code UNSPSC :
41116107
Nomenclature NACRES :
NA.24

Qualité

certified reference material

Niveau de qualité

300

Forme

liquid

Caractéristiques

Snap-N-Spike®/Snap-N-Shoot®

Conditionnement

ampule of 1 mL

Fabricant/nom de marque

Cerilliant®

Concentration

1.0 mg/mL in methanol

Technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

Application(s)

clinical testing

Format

single component solution

Température de stockage

−20°C

Chaîne SMILES 

CN1CCN2C(C1)c3ccccc3Cc4cccnc24

InChI

1S/C17H19N3/c1-19-9-10-20-16(12-19)15-7-3-2-5-13(15)11-14-6-4-8-18-17(14)20/h2-8,16H,9-12H2,1H3

Clé InChI

RONZAEMNMFQXRA-UHFFFAOYSA-N

Informations sur le gène

human ... ADRA2A(150) , ADRA2B(151) , ADRA2C(152) , HTR2A(3356) , HTR2C(3358)

Description générale

Mirtazapine is a tetracyclic antidepressant marketed under the trade names Remeron®, Avanza, or Zispin for treatment of depression. This Certified Spiking Solution® is suitable for LC/MS or GC/MS applications in forensic analysis, clinical toxicology, or urine drug testing.

Application


  • Mirtazapine research solution for CNS studies: A study on the nose-to-brain delivery of mirtazapine via lipid nanocapsules highlights its potential for enhanced CNS targeting, offering a promising approach for treating neurological conditions. This method aims to improve the bioavailability and therapeutic effectiveness of mirtazapine, showcasing its utility in pharmacokinetic research and CNS depressant studies (Ibrahim et al., 2024).

  • Mirtazapine liquid formulation for orally disintegrating tablets: Research into developing a novel direct compressible co-processed excipient for the formulation of mirtazapine orally disintegrating tablets emphasizes its importance in enhancing patient compliance and dosing accuracy. This study demonstrates mirtazapine′s role in pharmaceutical formulations, ensuring rapid onset of action which is critical in acute management of depressive episodes (Loke et al., 2024).

  • High-purity mirtazapine liquid for neurotransmitter research: A review linking stress, depression, and insulin resistance explores the systemic effects of chronic inflammation and the role of treatments like mirtazapine. This research underscores the importance of mirtazapine in understanding the biochemical pathways involved in chronic mental health disorders and their somatic comorbidities (Mehdi et al., 2023).

  • Stable mirtazapine formulation for opioid withdrawal treatment: Mirtazapine is explored as a one-stop strategy for the treatment of opioid withdrawal symptoms, highlighting its efficacy in reducing withdrawal severity and potentially lowering the dependency on traditional opioid replacement therapies. This application provides insights into mirtazapine′s versatility in treating complex drug dependencies (Lalani et al., 2023).

  • Mirtazapine aqueous solution for pharmacokinetic profiling: Research on the simultaneous separation and determination of several chiral antidepressants, including mirtazapine, in wastewater by two-dimensional liquid chromatography offers critical insights into environmental exposure and bioaccumulation risks. This study is pivotal for environmental safety and pharmaceutical dispersion monitoring, reflecting mirtazapine′s impact beyond clinical settings (Zhong et al., 2023).

Informations légales

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation
Remeron is a registered trademark of MSD
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Produit(s) apparenté(s)

Réf. du produit
Description
Tarif

Pictogrammes

FlameSkull and crossbonesHealth hazard
GHS02,GHS06,GHS08

Mention d'avertissement

Danger

Classification des risques

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

Organes cibles

Eyes

Code de la classe de stockage

3 - Flammable liquids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

49.5 °F - closed cup

Point d'éclair (°C)

9.7 °C - closed cup

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Seda G Sagdinc et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 104, 222-234 (2012-12-26)
Mirtazapine (±)-1,2,3,4,10,14b-hexahydro-2-methylpyrazino(2,1-a)pyrido(2,3-c)(2)benzazepine is a compound with antidepressant therapeutic effects. It is the 6-aza derivative of the tetracyclic antidepressant mianserin (±)-2-methyl-1,2,3,4,10,14b-hexahydrodibenzo[c,f]pyrazino[1,2-a]azepine. The FT-IR and FT-Raman spectra of mirtazapine have been recorded in 4000-400 cm(-1) and 3500-10 cm(-1), respectively. The optimized geometry
Xiaoyu Liu et al.
Neurochemical research, 38(9), 1973-1979 (2013-07-10)
Chemotherapic drugs may elicit acute or chronic peripheral neuropathies. Mirtazapine, as an antidepressant, is also used for the treatment of neuropathic pain. The current study aimed to investigate the effect of mirtazapine on the oxaliplatin-induced neuropathy in rats as well
Mustafa Gulec et al.
Psychiatry and clinical neurosciences, 67(1), 50-58 (2013-01-03)
Cisplatin chemotherapy is associated with neurotoxicity, and oxidative stress might play an important role in the pathogenesis. Mirtazapine may be a preventative agent via its less-known antioxidant properties. The aim of this study was to examine the potential chemoprotective effects
I Berling et al.
Clinical toxicology (Philadelphia, Pa.), 52(1), 20-24 (2013-11-16)
There is limited information on mirtazapine overdose, but cases of severe effects (seizures, serotonin toxicity and coma) have been reported. We aimed to investigate the clinical effects and complications of mirtazapine overdose. This was an observational case series of mirtazapine
Renee Romeo et al.
The British journal of psychiatry : the journal of mental science, 202, 121-128 (2012-12-22)
Depression is a common and costly comorbidity in dementia. There are very few data on the cost-effectiveness of antidepressants for depression in dementia and their effects on carer outcomes. To evaluate the cost-effectiveness of sertraline and mirtazapine compared with placebo
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