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M-105

Supelco

Methyl-D3-malonic acid solution

1.0 mg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant®

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About This Item

Formule empirique (notation de Hill):
C4H3O4D3
Numéro CAS:
42522-59-8
Poids moléculaire :
121.11
Numéro CE :
200-835-2
Code UNSPSC :
41116107
Nomenclature NACRES :
NA.24

Qualité

certified reference material

Niveau de qualité

300

Forme

liquid

Caractéristiques

Snap-N-Spike®/Snap-N-Shoot®

Conditionnement

ampule of 1 mL

Fabricant/nom de marque

Cerilliant®

Concentration

1.0 mg/mL in acetonitrile

Technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

Application(s)

clinical testing
pharmaceutical (small molecule)

Format

single component solution

Température de stockage

−20°C

Chaîne SMILES 

[2H]C([2H])([2H])C(C(O)=O)C(O)=O

InChI

1S/C4H6O4/c1-2(3(5)6)4(7)8/h2H,1H3,(H,5,6)(H,7,8)/i1D3

Clé InChI

ZIYVHBGGAOATLY-FIBGUPNXSA-N

Catégories apparentées

Description générale

Methylmalonic acid, a malonic acid derivative, is a vital intermediate in the metabolism of fat and proteins and plays a key role in energy metabolism. Elevated methylmalonic acid levels can be caused by an inborn error of metabolism leading to methylmalonic aciduria or indicate early vitamin B<sub>12</sub> deficiency. This internal standard is suitable for quantitation of methylmalonic acid levels by LC/MS or GC/MS in newborn screening and clinical testing applications to test for methylmalonic acidemia and diagnose vitamin B<sub>12</sub> deficiency.

Application



  • Assessment of Vitamin B-12 Status: Methyl-D3-malonic acid, as a deuterated derivative of malonic acid, was highlighted for its application in quantifying vitamin B-12 status using dried blood spots. This method provides a stable, precise measure and is useful in nutritional research and clinical diagnostics (Schroder et al., 2014).


  • Improvement of Analytical Methods: Methyl-D3-malonic acid was used in a gas chromatography-mass spectrometry (GC-MS) technique to quantify methylmalonic acid in serum. This application underlines its role in improving diagnostic assays by offering enhanced precision and reliability in biochemical measurements (Straczek et al., 1993).


Informations légales

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Pictogrammes

FlameExclamation mark
GHS02,GHS07

Mention d'avertissement

Danger

Classification des risques

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2

Code de la classe de stockage

3 - Flammable liquids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

35.6 °F - closed cup

Point d'éclair (°C)

2 °C - closed cup

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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