M-080
Methylmalonic acid solution
1.0 mg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant®
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About This Item
Produits recommandés
Qualité
certified reference material
Niveau de qualité
Forme
liquid
Caractéristiques
Snap-N-Spike®/Snap-N-Shoot®
Conditionnement
ampule of 1 mL
Fabricant/nom de marque
Cerilliant®
Concentration
1.0 mg/mL in acetonitrile
Technique(s)
gas chromatography (GC): suitable
liquid chromatography (LC): suitable
Application(s)
clinical testing
pharmaceutical (small molecule)
Format
single component solution
Température de stockage
−20°C
Chaîne SMILES
CC(C(O)=O)C(O)=O
InChI
1S/C4H6O4/c1-2(3(5)6)4(7)8/h2H,1H3,(H,5,6)(H,7,8)
Clé InChI
ZIYVHBGGAOATLY-UHFFFAOYSA-N
Description générale
Methylmalonic acid is an indicator of vitamin B12 deficiency and methylmalonic acidemia. This Certified Spiking Solution® is suitable for use in preparation of calibrators or controls in clinical and diagnostic testing using GC/MS or LC/MS.
Application
- Organic acid analysis for metabolic profiling: Research highlighted the integration of soil microbiota and metabolome, where methylmalonic acid was part of the metabolic profiling, revealing insights into how controlled release fertilizer impacts sugarcane growth, emphasizing the compound′s role in agricultural biotechnology (Yuan et al., 2023).
- Vitamin B12 deficiency research: Methylmalonic acid was featured in research on the cellular mechanisms affecting the MAFB/NOTCH3 axis in osteosarcoma, where its levels could potentially reflect perturbations relevant to vitamin B12 deficiency, aiding in better understanding of disease progression (Zhang et al., 2024).
- Methylmalonic acid standard for mass spectrometry analysis: The analysis of soybean root systems under varying nutrient conditions included methylmalonic acid as a standard in mass spectrometry to better understand nutrient uptake mechanisms, showcasing its utility in plant physiology and biochemistry studies (Qin et al., 2023).
Informations légales
CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany
Produit(s) apparenté(s)
Réf. du produit
Description
Tarif
Mention d'avertissement
Danger
Mentions de danger
Classification des risques
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2
Code de la classe de stockage
3 - Flammable liquids
Classe de danger pour l'eau (WGK)
WGK 2
Point d'éclair (°F)
35.6 °F - closed cup
Point d'éclair (°C)
2 °C - closed cup
Certificats d'analyse (COA)
Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".
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Les clients ont également consulté
Acute renal failure potentiates methylmalonate-induced oxidative stress in brain and kidney of rats.
P F Schuck et al.
Free radical research, 47(3), 233-240 (2013-01-10)
Tissue methylmalonic acid (MMA) accumulation is the biochemical hallmark of methylmalonic acidemia. The disease is clinically characterized by progressive neurological deterioration and kidney failure, whose pathophysiology is still unclear. In the present work we investigated the effects of acute MMA
Setareh Shahab-Ferdows et al.
The Journal of nutrition, 142(10), 1881-1887 (2012-08-24)
A high prevalence of low serum vitamin B-12 concentrations has been reported in studies and surveys in Latin America including Mexico, but the functional consequences are unknown. This randomized controlled trial assessed the response to a high-dose vitamin B-12 supplementation
Yu-peng Liu et al.
Zhonghua er ke za zhi = Chinese journal of pediatrics, 50(6), 410-414 (2012-08-31)
Methylmalonic aciduria is the most common disorder of organic acidurias in the mainland of China. It is also the one of treatable metabolic disorders. The clinical spectrum of the patients varies from severe neonatal-onset forms with neonatal brain injury and
Carla Dullemeijer et al.
The American journal of clinical nutrition, 97(2), 390-402 (2012-12-28)
Many randomized controlled trials (RCTs) and observational studies have provided information on the association between vitamin B-12 intake and biomarkers. The use of these data to estimate dose-response relations provides a useful means to summarize the body of evidence. We
Takayuki Watanabe et al.
Journal of feline medicine and surgery, 14(12), 942-945 (2012-08-22)
A 10-year-old domestic shorthair cat showed anorexia, lethargy and ptyalism with hyperammonaemia. Portosystemic shunts were not identified by computed tomography angiography. Biopsy results revealed mild interstinal nephritis and no lesion in the liver. Analysis of urine revealed the presence of
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