860677P
Avanti
C18 Ceramide-d7 (d18:1-d7/18:0)
Avanti Research™ - A Croda Brand 860677P, powder
Synonyme(s) :
N-stearoyl-D-erythro-sphingosine (d7)
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About This Item
Formule empirique (notation de Hill):
C36H64D7NO3
Numéro CAS:
Poids moléculaire :
573.00
Code UNSPSC :
12352100
Nomenclature NACRES :
NA.25
Produits recommandés
Forme
powder
Conditionnement
pkg of 1 × 1 mg (860677P-1mg)
Fabricant/nom de marque
Avanti Research™ - A Croda Brand 860677P
Conditions d'expédition
dry ice
Température de stockage
−20°C
Chaîne SMILES
OC[C@]([H])(NC(CCCCCCCCCCCCCCCCC)=O)[C@@](O)([H])/C=C/CCCCCCCCCCC(C(C([2H])([2H])[2H])([2H])[2H])([2H])[2H]
Description générale
C18 Ceramide (d18:1/18:0) is a synthetic ceramide containing sphingosine with stearic acid. C18 Ceramide-d7 (d18:1-d7/18:0) is a deuterated derivative of ceramide d18:1/18:0.
Application
C18 Ceramide-d7 (d18:1-d7/18:0) has been used as a standard in liquid chromatography–mass spectrometry (LC-MS) for quantitative analysis of C18 ceramide in skeletal muscle. It has also been used as a standard to measure C35–C39 ceramides in zebrafish brain and human embryonic kidney cell line (HEK293) by thermo q-exactive plus quadrupole-orbitrap mass spectrometery.
Actions biochimiques/physiologiques
C18 ceramide is involved in cell growth inhibition. Determining the levels of the ceramides (Cer) d18:1/16:0, Cer d18:1/18:0, Cer d18:1/24:0, and Cer d18:1/24:1 and ratios in human plasma enables the prognosis of fatal outcome of coronary artery disease. Stable isotope form of C18 ceramide d18:1/18:0 supports a newly described validated liquid chromatography-tandem mass spectrometry methodology for their clinical-scaled measurement.
Conditionnement
5 mL Amber Glass Screw Cap Vial (860677P-1mg)
Informations légales
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Souvent commandé avec ce produit
Réf. du produit
Description
Tarif
Code de la classe de stockage
11 - Combustible Solids
Point d'éclair (°F)
No data available
Point d'éclair (°C)
No data available
Certificats d'analyse (COA)
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Takhar Kasumov et al.
Analytical biochemistry, 401(1), 154-161 (2010-02-25)
We present an optimized and validated liquid chromatography electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS) method for the simultaneous measurement of concentrations of different ceramide species in biological samples. The method of analysis of tissue samples is based on Bligh and
Paul T Reidy et al.
The Journal of physiology, 596(21), 5217-5236 (2018-09-09)
Insulin sensitivity (as determined by a hyperinsulinaemic-euglyceamic clamp) decreased 15% after reduced activity. Despite not fully returning to baseline physical activity levels, insulin sensitivity unexpectedly, rebounded above that recorded before 2 weeks of reduced physical activity by 14% after the recovery
Anna Zalewska et al.
Biomolecules, 9(12) (2019-12-19)
This is the first study to investigate the relationship between ceramides, the mitochondrial respiratory system, oxidative stress, inflammation, and apoptosis in the submandibular gland mitochondria of mice with insulin resistance (IR). The experiment was conducted on 20 male C57BL/6 mice
Hady Razak Hady et al.
Journal of clinical medicine, 8(12) (2019-12-18)
The liver plays a central role in the glucose and lipid metabolism. Studies performed on animal models have shown an important role of lipid accumulation in the induction of insulin resistance. We sought to explain whether in obese humans, the
Tejia Zhang et al.
Scientific reports, 9(1), 19939-19939 (2019-12-29)
Extensive characterisations of the zebrafish genome and proteome have established a foundation for the use of the zebrafish as a model organism; however, characterisation of the zebrafish lipidome has not been as comprehensive. In an effort to expand current knowledge
Notre équipe de scientifiques dispose d'une expérience dans tous les secteurs de la recherche, notamment en sciences de la vie, science des matériaux, synthèse chimique, chromatographie, analyse et dans de nombreux autres domaines..
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