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857390P

Avanti

W146

(R)-3-Amino-(3-hexylphenylamino)-4-oxobutylphosphonic acid (TFA salt), powder

Synonyme(s) :

S1P1 Antagonist

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About This Item

Formule empirique (notation de Hill):
C18H28F3N2O6P
Numéro CAS:
909725-62-8
Poids moléculaire :
456.39
Code UNSPSC :
12352211
Nomenclature NACRES :
NA.25

Pureté

>99% (TLC)

Forme

powder

Conditionnement

pkg of 1 × 1 mg (857390P-1mg)
pkg of 1 × 10 mg (857390P-10mg)

Fabricant/nom de marque

Avanti Research™ - A Croda Brand 857390P

Type de lipide

sphingolipids

Conditions d'expédition

dry ice

Température de stockage

−20°C

Description générale

Compound 2a is a selective antagonist for human S1P1 (hS1P1) receptor activation by the physiological agonist S1P.
W146 is a sphingosine-1-phosphate 1 (S1P1) selective antagonist.

Application

W146 has been used:
  • to verify the mode of action of sphingosine-1-phosphate (S1P) in human bone marrow derived mesenchymal stem cells (hMSCs ) and primary human hepatogenic profibrotic cells (hHPCs)
  • to study oxidative stress and drug treatment in granulosa cells
  • to evaluate its effects on transendothelial electrical resistance (TEER)

Actions biochimiques/physiologiques

W146 acts as an orthosteric antagonist. It is linked to blood lymphopenia and lung edema in mice.

Conditionnement

5 mL Amber Glass Screw Cap Vial (857390P-10mg)
5 mL Amber Glass Screw Cap Vial (857390P-1mg)

Informations légales

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

No data available

Point d'éclair (°C)

No data available

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

The sphingosine-1-phosphate receptor-1 antagonist, W146, causes early and short-lasting peripheral blood lymphopenia in mice
Sphingosine-1-Phosphate Signaling in Immunology and Infectious Diseases (2014)
S1P, dihydro-S1P and C24: 1-ceramide levels in the HDL-containing fraction of serum inversely correlate with occurrence of ischemic heart disease
Argraves KM, et al.
Lipids in Health and Disease, 10(1), 70-70 (2011)
Sphingosine-1-phosphate inhibits H2O2-induced granulosa cell apoptosis via the PI3K/Akt signaling pathway
Nakahara T, et al.
Fertility and Sterility, 98(4) (2012)
M Germana Sanna et al.
Nature chemical biology, 2(8), 434-441 (2006-07-11)
Sphingosine 1-phosphate (S1P, 1) regulates vascular barrier and lymphoid development, as well as lymphocyte egress from lymphoid organs, by activating high-affinity S1P1 receptors. We used reversible chemical probes (i) to gain mechanistic insights into S1P systems organization not accessible through
Kelley M Argraves et al.
The Journal of biological chemistry, 283(36), 25074-25081 (2008-07-09)
High density lipoproteins (HDL) are major plasma carriers of sphingosine 1-phosphate (S1P). Here we show that HDL increases endothelial barrier integrity as measured by electric cell substrate impedance sensing. S1P was implicated as the mediator in this process through findings
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