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Merck
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Key Documents

810258E

Avanti

C11 TopFluor™ GM3

Avanti Research™ - A Croda Brand 810258E, ethanol solution

Synonyme(s) :

C11 TopFluor GM3 Ganglioside (ammonium salt)

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About This Item

Formule empirique (notation de Hill):
C65H110BF2N5O21
Numéro CAS:
2260795-48-8
Poids moléculaire :
1346.40
Code UNSPSC :
12352211
Nomenclature NACRES :
NA.25

Pureté

>99% (TLC)

Forme

ethanol solution

Conditionnement

pkg of 1 × 1 mL (810258E-100ug)

Fabricant/nom de marque

Avanti Research™ - A Croda Brand 810258E

Concentration

0.1 mg/mL (810258E-100ug)

Conditions d'expédition

dry ice

Température de stockage

−20°C

Catégories apparentées

Description générale

C11 TopFluor™ GM3 is a fluorescent analog of ganglioside GM3 (Siaa2-3Galb1-4Glcb1-1Cer).

Application

C11 TopFluor™ GM3 has been used to visualize GM3 present in UGCG-KO1.3 cells by immunofluorescence microscopy.

Actions biochimiques/physiologiques

Gangliosides function as modulators in regulating various receptor functions, involved in transmembrane signaling. GM3 plays an important role as a metabolic precursor for the formation of more complex gangliosides. It comprises between 80% and 90% of total ganglioside content in liver and adipose tissue, respectively. Additionally, GM3 is known to promote the subcellular redistribution of major caveolin enriched microdomain (CEM) components coordinating signal transduction. The increased levels of ganglioside GM3 in serum is reported in hyperlipidaemic, hyperglycaemic and type 2 diabetic patients.

Conditionnement

5 mL Amber Glass Screw Cap Vial (810258E-100ug)

Informations légales

Avanti Research is a trademark of Avanti Polar Lipids, LLC
TopFluor is a trademark of Avanti Polar Lipids, LLC

Pictogrammes

FlameExclamation mark
GHS02,GHS07

Mention d'avertissement

Danger

Mentions de danger

H225,H319

Classification des risques

Eye Irrit. 2 - Flam. Liq. 2

Code de la classe de stockage

3 - Flammable liquids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

55.4 °F - closed cup

Point d'éclair (°C)

13.0 °C - closed cup

Certificats d'analyse (COA)

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Seiichi Tagami et al.
The Journal of biological chemistry, 277(5), 3085-3092 (2001-11-15)
Gangliosides are known as modulators of transmembrane signaling by regulating various receptor functions. We have found that insulin resistance induced by tumor necrosis factor-alpha (TNF-alpha) in 3T3-L1 adipocytes was accompanied by increased GM3 ganglioside expression caused by elevating GM3 synthase
Christopher Lipina et al.
FEBS letters, 589(21), 3221-3227 (2015-10-06)
Gangliosides constitute a large family of sialic acid-containing glycosphingolipids which play a key regulatory role in a diverse array of cellular processes, including receptor-associated signalling. Accordingly, the aberrant production of the ganglioside GM3 has been linked to pathophysiological changes associated
Anshuman Das et al.
Nature microbiology, 5(9), 1069-1078 (2020-05-27)
The Picornaviridae are a diverse family of positive-strand RNA viruses that includes numerous human and veterinary pathogens1. Among these, hepatitis A virus (HAV), a common cause of acute hepatitis in humans, is unique in that it is hepatotropic and is
Jason G Kay et al.
Molecular biology of the cell, 23(11), 2198-2212 (2012-04-13)
Much has been learned about the role of exofacial phosphatidylserine (PS) in apoptosis and blood clotting using annexin V. However, because annexins are impermeant and unable to bind PS at low calcium concentration, they are unsuitable for intracellular use. Thus

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