QBD10501

Azido-dPEG^®₄-NHS ester

• Synonyme(s) : 3-(Azidotetra(ethyleneoxy))propionic acid succinimidyl ester, NHS-Peg4-Azide, Polyethylene glycol
• Formule empirique (notation de Hill): C₁₅H₂₄N₄O₈
• Numéro CAS: 944251-24-5
• Poids moléculaire : 388.37
• Numéro MDL: MFCD13184948
• Code UNSPSC : 12352108
• ID de substance PubChem : 329823930
• Nomenclature NACRES : NA.22

Propriétés

• Pureté: >90%
• Forme: solid or viscous liquid
• Capacité de réaction: reaction type: click chemistry
• Pertinence de la réaction: reagent type: cross-linking reagent; reaction type: click chemistry
• Groupe fonctionnel: NHS ester; azide
• Architecture des polymères: shape: linear; functionality: heterobifunctional
• Conditions d'expédition: ambient
• Température de stockage: −20°C
• Chaîne SMILES: O=C(ON1C(CCC1=O)=O)CCOCCOCCOCCOCCN=[N+]=[N-]
• InChI: 1S/C15H24N4O8/c16-18-17-4-6-24-8-10-26-12-11-25-9-7-23-5-3-15(22)27-19-13(20)1-2-14(19)21/h1-12H2
• Clé InChI: OIGKWPIMJCPGGD-UHFFFAOYSA-N

Description

Caractéristiques et avantages

The azido-dPEG^®₄-NHS ester contains an azide function on one end of a single molecular weight dPEG^® spacer (17.7 Å) and a reactive group on the other end of the spacer. The dPEG^® spacer is hydrophilic and non-immunogenic and improves the water solubility of the target molecule while reducing the immunogenicity and increasing the hydrodynamic volume of the target. NHS ester readily reacts with amines in aqueous solution or organic solvent. The azide group reacts with an alkyne in the well-known click chemistry reaction. The click chemistry reaction proceeds by copper(I) or ruthenium catalysis or in a strain-catalyzed reaction with certain types of alkyne partners.

Informations légales

Products Protected under U.S. Patents # 7,888,536 B2

dPEG is a registered trademark of Quanta BioDesign

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable