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QBD10273

Sigma-Aldrich

Fmoc-N-amido-dPEG®8-acid

>95% (HPLC)

Synonyme(s) :

Fmoc-N-amido-PEG8-COOH, Fmoc-N-amido-PEG8-acid, Fmoc-NH-PEG8-acid, Fmoc-PEG-acid

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About This Item

Formule empirique (notation de Hill):
C34H49NO12
Poids moléculaire :
663.75
Numéro MDL:
MFCD11041143
Code UNSPSC :
12352106
Nomenclature NACRES :
NA.22

Pureté

>95% (HPLC)

Forme

solid or viscous liquid

Capacité de réaction

reaction type: Pegylations

Architecture des polymères

shape: linear
functionality: heterobifunctional

Conditions d'expédition

ambient

Température de stockage

−20°C

Caractéristiques et avantages

Fmoc-N-amido-dPEG8-acid is a monodisperse PEG product that is useful for peptide synthesis. The 28-atom dPEG spacer allows the introduction of a medium-length, hydrophilic spacer onto either end of a peptide chain or between two peptide chains. The flexible dPEG spacer conjugates to peptides using conventional peptide synthesis chemistry. Peptide PEGylation imparts water solubility to hydrophobic peptide chains. Also, PEGylated peptides have expanded hydrodynamic volumes, which can reduce or eliminate renal clearance, and are protected from proteolysis. The combination of decreased renal clearance and protection from proteolysis contributes to longer in vivo circulation times for PEGylated (as compared to non-PEGylated) peptides. Additionally, PEGylation diminishes a peptide′s antigenicity. This product is part of the Fmoc-N-amido-dPEGn-acid (n=2, 3, 4, 5, 6, 8, 12, 24, 36) product series.

Informations légales

Products Protected under U.S. Patent #s 7,888,536 & 8,637,711 and European Patent #s 1,594,440 & 2,750,681
dPEG is a registered trademark of Quanta BioDesign

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Lot/Batch Number

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Guangchang Zhou et al.
Molecular bioSystems, 8(9), 2395-2404 (2012-07-10)
Robust methods for highly parallel, quantitative analysis of cellular protein tyrosine kinase activities may provide tools critically needed to decipher oncogenic signaling, discover new targeted drugs, diagnose cancer and monitor patients. Here, we describe proof-of-principle for a novel protein kinase
Ignacio Melgar-Asensio et al.
Investigative ophthalmology & visual science, 59(10), 4071-4081 (2018-08-12)
Drug delivery by intravitreal injection remains problematic, small agents and macromolecules both clearing rapidly. Typical carriers use microparticles (>2 μm), with size-related liabilities, to slow diffusion. We recently described cationic nanoparticles (NP) where conjugated Arg peptides prolonged residence in rat
Ian W Hamley
Biomacromolecules, 15(5), 1543-1559 (2014-04-12)
The remarkable diversity of the self-assembly behavior of PEG-peptides is reviewed, including self-assemblies formed by PEG-peptides with β-sheet and α-helical (coiled-coil) peptide sequences. The modes of self-assembly in solution and in the solid state are discussed. Additionally, applications in bionanotechnology
Jared F Stefanick et al.
ACS nano, 7(9), 8115-8127 (2013-09-06)
Ligand-targeted nanoparticles are emerging drug delivery vehicles for cancer therapy. Here, we demonstrate that the cellular uptake of peptide-targeted liposomes and micelles can be significantly enhanced by increasing the hydrophilicity of the targeting peptide sequence while simultaneously optimizing the EG

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