QBD10243
Fmoc-N-amido-dPEG®2-acid
>95% (HPLC)
Synonyme(s) :
Fmoc-N-amido-PEG2-COOH, Fmoc-N-amido-PEG2-acid, Fmoc-PEG-acid, Fmoc-PEG2-acid
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About This Item
Formule empirique (notation de Hill):
C22H25NO6
Poids moléculaire :
399.44
Numéro MDL:
Code UNSPSC :
12352106
Nomenclature NACRES :
NA.22
Produits recommandés
Pureté
>95% (HPLC)
Forme
solid or viscous liquid
Capacité de réaction
reaction type: Pegylations
Architecture des polymères
shape: linear
functionality: homobifunctional
Conditions d'expédition
ambient
Température de stockage
−20°C
Caractéristiques et avantages
Fmoc-N-amido-dPEG2-acid is a monodisperse PEG product that is useful for peptide synthesis. The ten-atom dPEG spacer allows the introduction of a short, hydrophilic spacer onto either end of a peptide chain or between two peptide chains. The flexible dPEG spacer conjugates to peptides using conventional peptide synthesis chemistry. Peptide PEGylation imparts water solubility to hydrophobic peptide chains. Also, PEGylated peptides have expanded hydrodynamic volumes, which can reduce or eliminate renal clearance, and are protected from proteolysis. The combination of decreased renal clearance and protection from proteolysis contributes to longer in vivo circulation times for PEGylated (as compared to non-PEGylated) peptides. Additionally, PEGylation diminishes a peptide′s antigenicity. This product is part of the Fmoc-N-amido-dPEGn-acid (n=2, 3, 4, 5, 6, 8, 12, 24, 36) product series.
Informations légales
Products Protected under U.S. Patent #s 7,888,536 & 8,637,711 and European Patent #s 1,594,440 & 2,750,681
dPEG is a registered trademark of Quanta BioDesign
Code de la classe de stockage
11 - Combustible Solids
Classe de danger pour l'eau (WGK)
WGK 3
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
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Ananda Kumar Kanduluru et al.
Bioconjugate chemistry, 27(9), 2157-2165 (2016-08-17)
The neurokinin-1 receptor (NK1R) is implicated in the growth and metastasis of many tumors, including cancers of the brain (e.g., gliomas, glioblastomas, and astrocytomas), skin (e.g., melanomas), and neuroendocrine tissues (cancers of the breast, stomach, pancreas, larynx, and colon). Because
Aaron S Anderson et al.
Langmuir : the ACS journal of surfaces and colloids, 24(5), 2240-2247 (2008-01-31)
We report a general procedure to prepare functional organic thin films for biological assays on oxide surfaces. Silica surfaces were functionalized by self-assembly of an amine-terminated silane film using both vapor- and solution-phase deposition of 3'-aminopropylmethyldiethoxysilane (APMDES). We found that
Jered C Garrison et al.
Bioconjugate chemistry, 19(9), 1803-1812 (2008-08-21)
The high incidence of BB2 receptor (BB2r) expression in various cancers has prompted investigators to pursue the development of BB2r-targeted agents for diagnostic imaging, chemotherapy, and radiotherapy. Development of BB2r-targeted agents, based on the bombesin (BBN) peptide, has largely involved
Ian W Hamley
Biomacromolecules, 15(5), 1543-1559 (2014-04-12)
The remarkable diversity of the self-assembly behavior of PEG-peptides is reviewed, including self-assemblies formed by PEG-peptides with β-sheet and α-helical (coiled-coil) peptide sequences. The modes of self-assembly in solution and in the solid state are discussed. Additionally, applications in bionanotechnology
Jared F Stefanick et al.
ACS nano, 7(9), 8115-8127 (2013-09-06)
Ligand-targeted nanoparticles are emerging drug delivery vehicles for cancer therapy. Here, we demonstrate that the cellular uptake of peptide-targeted liposomes and micelles can be significantly enhanced by increasing the hydrophilicity of the targeting peptide sequence while simultaneously optimizing the EG
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