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K6000

Sigma-Aldrich

α-Keto-γ-(methylthio)butyric acid sodium salt

≥97%

Synonyme(s) :

4-Methylthio-2-oxobutanoic acid sodium salt, 4-Methylthio-2-oxobutyric acid sodium salt, KMBA

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About This Item

Formule linéaire :
C5H7O3SNa
Numéro CAS:
51828-97-8
Poids moléculaire :
170.16
Numéro MDL:
MFCD00010511
Code UNSPSC :
12352100
ID de substance PubChem :
57654320
Nomenclature NACRES :
NA.22

Niveau de qualité

200

Pureté

≥97%

Température de stockage

2-8°C

Chaîne SMILES 

[Na].CSCCC(=O)C(O)=O

InChI

1S/C5H8O3S.Na/c1-9-3-2-4(6)5(7)8;/h2-3H2,1H3,(H,7,8);/q;+1/p-1

Clé InChI

IFSCKRWNXKWTLR-UHFFFAOYSA-M

Catégories apparentées

Description générale

α-Keto-γ-methylthiobutyric acid (KMTB) is a keto derivative of L-methionine that shows considerable potential as a substitute for L-methionine. The sodium salt of KMTB can be employed in nucleophilic substitution reactions. Additionally, it acts as a building block for the synthesis of amino acids, peptides, and other complex organic compounds.

Application


  • Measuring antioxidant capacity using the ORAC and TOSC assays.: This study details the use of α-Keto-γ-(methylthio)butyric acid sodium salt in assessing antioxidant capacity through ORAC and TOSC assays, emphasizing its utility in metabolic and chemical synthesis research (Garrett AR et al., 2010).

Pictogrammes

Exclamation mark
GHS07

Mention d'avertissement

Warning

Mentions de danger

H315,H319,H335

Classification des risques

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Organes cibles

Respiratory system

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

dust mask type N95 (US), Eyeshields, Gloves

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Certificats d'analyse (COA)

Lot/Batch Number
0000324854
0000269941
0000269942
SLCL6007
SLBV3179

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Charlotte Sandersen et al.
Veterinary anaesthesia and analgesia, 38(2), 83-93 (2011-02-10)
To investigate the effect of acepromazine (ACP) on reactive oxygen species (ROS) production by stimulated equine neutrophils. Ex vivo biochemical experiments. Isolated neutrophils from healthy untreated horses. Neutrophils were incubated with ACP at concentrations of 10(-4), 10(-5) or 10(-6) M
F Regoli et al.
Toxicology and applied pharmacology, 156(2), 96-105 (1999-04-13)
We have extended the application of our previously reported total oxidant scavenging capacity (TOSC) assay (Winston et al., Free Radical Biol. Med. 24, 480-493, 1998) to permit facile quantification of the absorbance capacity of antioxidants toward three potent oxidants, i.e.
Michael W Straza et al.
Cell cycle (Georgetown, Tex.), 9(18), 3740-3750 (2010-10-12)
The CtBP transcriptional corepressors promote cancer cell survival and migration/invasion. CtBP senses cellular metabolism via a regulatory dehydrogenase domain, and is antagonized by p14/p19(ARF) tumor suppressors. The CtBP dehydrogenase substrate 4-methylthio-2-oxobutyric acid (MTOB) can act as a CtBP inhibitor at
Gary W Winston et al.
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP, 139(4), 281-288 (2005-02-03)
During embryogenesis in grass shrimp the capacity to scavenge oxyradicals increased as measured by the Total Oxyradical Scavenging Capacity (TOSC) assay. The increase in TOSC during embryogenesis was associated with increasing concentrations of a number of antioxidants, including coenzyme Q
Manas K Chattopadhyay et al.
Proceedings of the National Academy of Sciences of the United States of America, 102(45), 16158-16163 (2005-11-02)
Methylthioadenosine is formed during the biosynthesis of spermidine and of spermine and is metabolized by methylthioadenosine phosphorylase, an enzyme missing in several tumor cell lines. In Saccharomyces cerevisiae, this enzyme is coded by the MEU1 gene. We have now studied
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