907286

H-L-Photo-Proline hydrochloride

≥95%, for peptide synthesis

• Synonyme(s) : (S)-1,2,5-Triazaspiro[2.4]hept-1-ene-6-carboxylic acid, Diazirine amino acid, Photo-Pro, Photo-crosslinking amino acid, Photoprobe building block
• Formule empirique (notation de Hill): C₅H₈ClN₃O₂
• Poids moléculaire : 177.59
• Code UNSPSC : 12352101
• Nomenclature NACRES : NA.22

Propriétés

• product name: H-L-Photo-Proline hydrochloride, ≥95%
• Pureté: ≥95%
• Forme: powder
• Capacité de réaction: reaction type: solution phase peptide synthesis
• Application(s): peptide synthesis
• Température de stockage: −20°C

Description

Application

H-L-Photo-Proline HCl is a diazirine-containing proline amino acid and multifunctional probe building blocks. Its incorporation into peptides or small-molecule probes and tools allows for photoaffinity labeling of cellular targets and protein-protein interactions upon UV light (∼360 nm) irradiation to form a covalent bond. This and other multifunctional probe building blocks will continue to accelerate drug discovery research for probing cellular mechanisms, target ID/validation, and understanding traditionally undruggable targets. An Fmoc-protected version is also available as 907324.

Product can be used with our line of photoreactors: Including Penn PhD (Z744035) & SynLED 2.0 (Z744080)

Autres remarques

Fishing for Drug Targets: A Focus on Diazirine Photoaffinity Probe Synthesis

Photo-affinity labeling (PAL) in chemical proteomics: a handy tool to investigate protein-protein interactions (PPIs)

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable