901355
Polyester bis-MPA dendron
16 acetylene, 1 NHBoc (core), generation 4
Synonyme(s) :
Bis-MPA dendron, PFd-G4-BocNH-acetylene
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About This Item
Formule empirique (notation de Hill) :
C203H247NO101
Poids moléculaire :
4317.08
Code UNSPSC :
12162002
Nomenclature NACRES :
NA.23
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Description générale
- Polymer architecture: Dendron
- Generation: 4
- Core functional group: Boc-protected amine
- End group functionality: Alkyne
- No. surface groups: 16
- Calculated mol. wt.: 4317.12 g/mol
- Boc: tert-Butyloxycarbonyl
- Bis-MPA: 2,2-Bis(hydroxymethyl)propionic acid
Application
Bis-MPA (or 2,2-bis(methylol)propionic acid) is an aliphatic, pro-chiral molecule comprised of two hydroxyls and one carboxylic group that has been used in the synthesis of many different types of polymers. Dendrons synthesized from bis-MPA are biodegradable and have low cytotoxicity, making them well suited for use in biological research applications. These materials have been used in many applications such as signal amplification in bioassays and in drug delivery applications. These alkyne-functionalized dendrimers can be readily functionalized using either copper(I)-catalysed alkyne-azide cycloaddition (CuAAC), strain-promoted alkyne-azide cycloaddition (SPAAC), or thiol-yne click reactions. Additionally, the amine-functionalized core can be readily used in EDC or DCC coupling reactions (after Boc deprotection) with carbonyl-containing compounds to yield highly functionalized materials for a variety of biomedical applications.
Code de la classe de stockage
11 - Combustible Solids
Classe de danger pour l'eau (WGK)
WGK 3
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.
Anna Carlmark et al.
Chemical Society reviews, 42(13), 5858-5879 (2013-05-01)
Dendritic polymers are highly branched, globular architectures with multiple representations of functional groups. These nanoscale organic frameworks continue to fascinate researchers worldwide and are today under intensive investigation in application-driven research. A large number of potential application areas have been
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