49920

Glycerol formal

≥98.0% (GC)

• Synonyme(s) : 1,3(or 2,3)-O-Methylene-1,2,3-propanetriol
• Formule empirique (notation de Hill): C₄H₈O₃
• Numéro CAS: 99569-11-6
• Poids moléculaire : 104.10
• Numéro Beilstein : 103206
• Numéro MDL: MFCD10039829
• Code UNSPSC : 12352100
• ID de substance PubChem : 57651229
• Nomenclature NACRES : NA.22

Propriétés

• Niveau de qualité: 200
• Pureté: ≥98.0% (GC)
• Contient: ~0.02% 2,6-di-tert-butyl-4-methylphenol as stabilizer
• Composition: 5-hydroxy-1,3-dioxane, ~60% ; 4-hydroxymethyl-1,3-dioxolane, ~40%
• Indice de réfraction: n20/D 1.451 (lit.); n20/D 1.451
• Point d'ébullition: 192-193 °C (lit.)
• Densité: 1.203 g/mL at 25 °C (lit.)
• Groupe fonctionnel: ether; hydroxyl
• Chaîne SMILES: OCC1COCO1.OC2COCOC2
• InChI: 1S/2C4H8O3/c5-4-1-6-3-7-2-4;5-1-4-2-6-3-7-4/h2*4-5H,1-3H2
• Clé InChI: JIUMSISXCKWZTA-UHFFFAOYSA-N

Description

Description générale

Glycerol formal (GF) is a light glycerol acetal that is composed of ~60% 5-hydroxy-1,3-dioxane and ~40% 4-hydroxymethyl-1,3-dioxolane. It can be prepared by reacting glycerol and formaldehyde in the presence of acid catalyst. The potential of GF as an injection solvent for use in toxicity testing has been reported.

Application

Glycerol formal is used to to solubilize water-insoluble compounds for subsequent aqueous dilution. It has been used as a chemical and dye emulsifier and as a cosolvent for drug delivery. Glycerol formal was used as a vehicle for antibiotic delivery in rats.

Glycerol formal may be used in the multi-step synthesis of 9-[(2-hydroxy-1-(hydroxymethyl)ethoxy)methyl]guanine (2′-nor-2′-deoxyguanosine), an analog of acyclovir. It may be used in the preparation of 4-substituted dioxolanes.

Informations sur la sécurité

• Classe de danger pour l'eau (WGK): WGK 3
• Équipement de protection individuelle: Eyeshields, Gloves, type ABEK (EN14387) respirator filter