366315

Tris(dibenzylideneacetone)dipalladium(0)-chloroform adduct

• Synonyme(s) : Dipalladium-tris(dibenzylideneacetone)chloroform complex, Pd₂(dba)₃ · CHCl₃
• Formule linéaire : (C₆H₅CH=CHCOCH=CHC₆H₅)₃Pd₂ · CHCl₃
• Numéro CAS: 52522-40-4
• Poids moléculaire : 1035.10
• Numéro MDL: MFCD00075479
• Code UNSPSC : 12161600
• ID de substance PubChem : 24862642
• Nomenclature NACRES : NA.22

Propriétés

• Forme: solid
• Niveau de qualité: 100
• Pertinence de la réaction: core: palladium; reagent type: catalyst
• Capacité de réaction: reaction type: Buchwald-Hartwig Cross Coupling Reaction; reaction type: Cross Couplings; reaction type: Heck Reaction; reaction type: Hiyama Coupling; reaction type: Negishi Coupling; reaction type: Sonogashira Coupling; reaction type: Stille Coupling; reaction type: Suzuki-Miyaura Coupling
• Pf: 131-135 °C (lit.)
• Chaîne SMILES: [Pd].[Pd].ClC(Cl)Cl.O=C(/C=C/c1ccccc1)\C=C\c2ccccc2.O=C(/C=C/c3ccccc3)\C=C\c4ccccc4.O=C(\C=C\c5ccccc5)/C=C/c6ccccc6
• InChI: 1S/3C17H14O.CHCl3.2Pd/c3*18-17(13-11-15-7-3-1-4-8-15)14-12-16-9-5-2-6-10-16;2-1(3)4;;/h3*1-14H;1H;;/b3*13-11+,14-12+;;;
• Clé InChI: LNAMMBFJMYMQTO-FNEBRGMMSA-N

Description

Description générale

Tris(dibenzylideneacetone)dipalladium(0)-chloroform adduct (Pd₂dba₃·CHCl₃) is reported to serve as effective precatalysts, or precursors to the active Pd(0) catalyst.[1]

Application

Application Guide for Palladium Catalyzed Cross-Coupling Reactions

Tris(dibenzylideneacetone)dipalladium(0)-chloroform adduct (Pd₂dba₃·CHCl₃) was used in the following studies:

• To compose the catalytic system for the preparation of homoallylpalladium complexes.These complexes underwent in situ Stille type cross coupling with various vinyltin reagents to afford the cyclized products bearing allyl appendages.[2]
• As palladium source in the asymmetric transformations of 3,4-epoxy-1-butene.[3]
• As catalyst for the Heck cross-coupling reaction of iodobenzene with styrene.[1]
• As cyclization catalyst.[4][5]
• As catalyst for [2+2+2] cycloaddtion of didehydrotriphenylenes to the corresponding extended triphenylenes.[6]
• As catalyst for the carbonylation of b,b-imidoyl iodides to the corresponding imidate esters used, in turn, to prepare cyclic, quaternary amino acids.[7]

Informations sur la sécurité

• Pictogrammes: GHS08,GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H302,H315,H351
• Conseils de prudence: P201 - P202 - P264 - P301 + P312 - P302 + P352 - P308 + P313
• Classification des risques: Acute Tox. 4 Oral - Carc. 2 - Skin Irrit. 2
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Gloves