361941

Di-tert-butyl dicarbonate

≥99%, for peptide synthesis, ReagentPlus^®

• Synonyme(s) : Boc anhydride, Di-tert-butyl pyrocarbonate
• Formule linéaire : [(CH₃)₃COCO]₂O
• Numéro CAS: 24424-99-5
• Poids moléculaire : 218.25
• Numéro Beilstein : 1911173
• Numéro CE : 246-240-1
• Numéro MDL: MFCD00008805
• Code UNSPSC : 12352302
• ID de substance PubChem : 24862282
• Nomenclature NACRES : NA.22

Propriétés

• product name: Di-tert-butyl dicarbonate, ReagentPlus^®, ≥99%
• Niveau de qualité: 200
• Gamme de produits: ReagentPlus^®
• Pureté: ≥99%
• Forme: solid or liquid
• Indice de réfraction: n20/D 1.409 (lit.)
• Point d'ébullition: 56-57 °C/0.5 mmHg (lit.)
• Pf: 23 °C (lit.)
• Densité: 0.95 g/mL at 25 °C (lit.)
• Application(s): peptide synthesis
• Groupe fonctionnel: carbonate
• Température de stockage: 2-8°C
• Chaîne SMILES: CC(C)(C)OC(=O)OC(=O)OC(C)(C)C
• InChI: 1S/C10H18O5/c1-9(2,3)14-7(11)13-8(12)15-10(4,5)6/h1-6H3
• Clé InChI: DYHSDKLCOJIUFX-UHFFFAOYSA-N

Description

Application

Automated Boc protection and deprotection can be done using Synple Automated Synthesis Platform (SYNPLE-SC002), Boc protection cartridges ((SYNPLE-B001), (SYNPLE-B002), and Boc deprotection cartridges (SYNPLE-B011)

Di-tert-butyl dicarbonate (Boc anhydride) can be used:

• As a reagent to introduce Boc protecting group for the amine functionalities.
• To prepare tert-butyl ethers and Boc-alcohols in presence of Lewis acid catalyst.
• As a carboxylating agent for the preparation of a variety of tert-butyl carboxylates.
• For the conversion of amines to corresponding isocyanates, carbamates and urea derivatives.
• As a coupling reagent for anchoring various carboxylic acids to hydroxymethylated resins.
• To synthesize quinolinones and 2-(pseudo)haloquinolines from 2-alkenylanilines in presence of DMAP as a catalyst.

Reagent for the introduction of the Boc protecting group.

Avertissement

Hydrolyzes to t-butanol and CO₂; causes internal pressure in bottle if exposed to moisture.

Informations légales

ReagentPlus is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Pictogrammes: GHS02,GHS06,GHS05
• Mention d'avertissement: Danger
• Mentions de danger: H226,H315,H317,H318,H330,H335
• Conseils de prudence: P210 - P233 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• Classification des risques: Acute Tox. 1 Inhalation - Eye Dam. 1 - Flam. Liq. 3 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
• Organes cibles: Respiratory system
• Code de la classe de stockage: 3 - Flammable liquids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): 98.6 °F - closed cup
• Point d'éclair (°C): 37 °C - closed cup
• Équipement de protection individuelle: Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter